Mesenchymal Stromal Cells for Transplant Tolerance

Manuel Alfredo Podestà, Giuseppe Remuzzi, Federica Casiraghi

Research output: Contribution to journalReview articlepeer-review

Abstract

In solid organ transplantation lifelong immunosuppression exposes transplant recipients to life-threatening complications, such as infections and malignancies, and to severe side effects. Cellular therapy with mesenchymal stromal cells (MSC) has recently emerged as a promising strategy to regulate anti-donor immune responses, allowing immunosuppressive drug minimization and tolerance induction. In this review we summarize preclinical data on MSC in solid organ transplant models, focusing on potential mechanisms of action of MSC, including down-regulation of effector T-cell response and activation of regulatory pathways. We will also provide an overview of available data on safety and feasibility of MSC therapy in solid organ transplant patients, highlighting the issues that still need to be addressed before establishing MSC as a safe and effective tolerogenic cell therapy in transplantation.

Original languageEnglish
Pages (from-to)1287
JournalFrontiers in Immunology
Volume10
DOIs
Publication statusPublished - 2019

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