Mesenchymal/radioresistant traits in granular astrocytomas: evidence from a combined clinical and molecular approach

Rebecca Senetta, Marta Mellai, Claudia Manini, Isabella Castellano, Luca Bertero, Alessandra Pittaro, Davide Schiffer, Renzo Boldorini, Paola Cassoni

Research output: Contribution to journalArticle

Abstract

Aims: Granular-cell astrocytomas (GCAs) are morphologically characterized by a prominent component of granular periodic acid–Schiff-positive cells, and show increased aggressiveness as compared with ‘ordinary’ astrocytomas. The aim of this study was to investigate, in a small series of three GCAs, the expression of mesenchymal/radioresistance-associated biomarkers [such as chitinase-3-like protein 1 (YKL-40), hepatocyte growth factor receptor (c-Met), and caveolin 1 (Cav1)] that could contribute to the poor outcome associated with this glioma subgroup. Methods and results: Our results show that GCAs, according to the new molecular glioma classifications, consistently show a prognostically negative molecular trait (IDH1wt-ATRX noloss-1p/19q nocodeletion). Furthermore, GCAs significantly differed from a control series of 33 ‘conventional’ astrocytomas, because of diffuse and strong immunohistochemical coexpression of YKL-40, c-Met, and Cav1. Conclusions: Our findings show that specific morphological traits, such as a granular-cell component, could represent useful features in guiding the search for prognostic and predictive biomarkers that could eventually be therapy-targetable (e.g. Met inhibitors aimed at reducing radioresistance).

Original languageEnglish
Pages (from-to)329-337
Number of pages9
JournalHistopathology
Volume69
Issue number2
DOIs
Publication statusPublished - Aug 1 2016

Keywords

  • c-Met
  • Cav1
  • granular-cell astrocytoma
  • granular-cell glioblastoma
  • YKL-40

ASJC Scopus subject areas

  • Histology
  • Pathology and Forensic Medicine

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    Senetta, R., Mellai, M., Manini, C., Castellano, I., Bertero, L., Pittaro, A., Schiffer, D., Boldorini, R., & Cassoni, P. (2016). Mesenchymal/radioresistant traits in granular astrocytomas: evidence from a combined clinical and molecular approach. Histopathology, 69(2), 329-337. https://doi.org/10.1111/his.12944