Mesenchymal/radioresistant traits in granular astrocytomas: evidence from a combined clinical and molecular approach

Rebecca Senetta, Marta Mellai, Claudia Manini, Isabella Castellano, Luca Bertero, Alessandra Pittaro, Davide Schiffer, Renzo Boldorini, Paola Cassoni

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Aims: Granular-cell astrocytomas (GCAs) are morphologically characterized by a prominent component of granular periodic acid–Schiff-positive cells, and show increased aggressiveness as compared with ‘ordinary’ astrocytomas. The aim of this study was to investigate, in a small series of three GCAs, the expression of mesenchymal/radioresistance-associated biomarkers [such as chitinase-3-like protein 1 (YKL-40), hepatocyte growth factor receptor (c-Met), and caveolin 1 (Cav1)] that could contribute to the poor outcome associated with this glioma subgroup. Methods and results: Our results show that GCAs, according to the new molecular glioma classifications, consistently show a prognostically negative molecular trait (IDH1wt-ATRX noloss-1p/19q nocodeletion). Furthermore, GCAs significantly differed from a control series of 33 ‘conventional’ astrocytomas, because of diffuse and strong immunohistochemical coexpression of YKL-40, c-Met, and Cav1. Conclusions: Our findings show that specific morphological traits, such as a granular-cell component, could represent useful features in guiding the search for prognostic and predictive biomarkers that could eventually be therapy-targetable (e.g. Met inhibitors aimed at reducing radioresistance).

Original languageEnglish
Pages (from-to)329-337
Number of pages9
JournalHistopathology
Volume69
Issue number2
DOIs
Publication statusPublished - Aug 1 2016

Fingerprint

Astrocytoma
Caveolin 1
Glioma
Biomarkers
Proto-Oncogene Proteins c-met
Cellular Structures

Keywords

  • c-Met
  • Cav1
  • granular-cell astrocytoma
  • granular-cell glioblastoma
  • YKL-40

ASJC Scopus subject areas

  • Histology
  • Pathology and Forensic Medicine

Cite this

Senetta, R., Mellai, M., Manini, C., Castellano, I., Bertero, L., Pittaro, A., ... Cassoni, P. (2016). Mesenchymal/radioresistant traits in granular astrocytomas: evidence from a combined clinical and molecular approach. Histopathology, 69(2), 329-337. https://doi.org/10.1111/his.12944

Mesenchymal/radioresistant traits in granular astrocytomas : evidence from a combined clinical and molecular approach. / Senetta, Rebecca; Mellai, Marta; Manini, Claudia; Castellano, Isabella; Bertero, Luca; Pittaro, Alessandra; Schiffer, Davide; Boldorini, Renzo; Cassoni, Paola.

In: Histopathology, Vol. 69, No. 2, 01.08.2016, p. 329-337.

Research output: Contribution to journalArticle

Senetta, R, Mellai, M, Manini, C, Castellano, I, Bertero, L, Pittaro, A, Schiffer, D, Boldorini, R & Cassoni, P 2016, 'Mesenchymal/radioresistant traits in granular astrocytomas: evidence from a combined clinical and molecular approach', Histopathology, vol. 69, no. 2, pp. 329-337. https://doi.org/10.1111/his.12944
Senetta, Rebecca ; Mellai, Marta ; Manini, Claudia ; Castellano, Isabella ; Bertero, Luca ; Pittaro, Alessandra ; Schiffer, Davide ; Boldorini, Renzo ; Cassoni, Paola. / Mesenchymal/radioresistant traits in granular astrocytomas : evidence from a combined clinical and molecular approach. In: Histopathology. 2016 ; Vol. 69, No. 2. pp. 329-337.
@article{dc4ba8a4e815453ab326a9283f3b3a78,
title = "Mesenchymal/radioresistant traits in granular astrocytomas: evidence from a combined clinical and molecular approach",
abstract = "Aims: Granular-cell astrocytomas (GCAs) are morphologically characterized by a prominent component of granular periodic acid–Schiff-positive cells, and show increased aggressiveness as compared with ‘ordinary’ astrocytomas. The aim of this study was to investigate, in a small series of three GCAs, the expression of mesenchymal/radioresistance-associated biomarkers [such as chitinase-3-like protein 1 (YKL-40), hepatocyte growth factor receptor (c-Met), and caveolin 1 (Cav1)] that could contribute to the poor outcome associated with this glioma subgroup. Methods and results: Our results show that GCAs, according to the new molecular glioma classifications, consistently show a prognostically negative molecular trait (IDH1wt-ATRX noloss-1p/19q nocodeletion). Furthermore, GCAs significantly differed from a control series of 33 ‘conventional’ astrocytomas, because of diffuse and strong immunohistochemical coexpression of YKL-40, c-Met, and Cav1. Conclusions: Our findings show that specific morphological traits, such as a granular-cell component, could represent useful features in guiding the search for prognostic and predictive biomarkers that could eventually be therapy-targetable (e.g. Met inhibitors aimed at reducing radioresistance).",
keywords = "c-Met, Cav1, granular-cell astrocytoma, granular-cell glioblastoma, YKL-40",
author = "Rebecca Senetta and Marta Mellai and Claudia Manini and Isabella Castellano and Luca Bertero and Alessandra Pittaro and Davide Schiffer and Renzo Boldorini and Paola Cassoni",
year = "2016",
month = "8",
day = "1",
doi = "10.1111/his.12944",
language = "English",
volume = "69",
pages = "329--337",
journal = "Histopathology",
issn = "0309-0167",
publisher = "Wiley-Blackwell",
number = "2",

}

TY - JOUR

T1 - Mesenchymal/radioresistant traits in granular astrocytomas

T2 - evidence from a combined clinical and molecular approach

AU - Senetta, Rebecca

AU - Mellai, Marta

AU - Manini, Claudia

AU - Castellano, Isabella

AU - Bertero, Luca

AU - Pittaro, Alessandra

AU - Schiffer, Davide

AU - Boldorini, Renzo

AU - Cassoni, Paola

PY - 2016/8/1

Y1 - 2016/8/1

N2 - Aims: Granular-cell astrocytomas (GCAs) are morphologically characterized by a prominent component of granular periodic acid–Schiff-positive cells, and show increased aggressiveness as compared with ‘ordinary’ astrocytomas. The aim of this study was to investigate, in a small series of three GCAs, the expression of mesenchymal/radioresistance-associated biomarkers [such as chitinase-3-like protein 1 (YKL-40), hepatocyte growth factor receptor (c-Met), and caveolin 1 (Cav1)] that could contribute to the poor outcome associated with this glioma subgroup. Methods and results: Our results show that GCAs, according to the new molecular glioma classifications, consistently show a prognostically negative molecular trait (IDH1wt-ATRX noloss-1p/19q nocodeletion). Furthermore, GCAs significantly differed from a control series of 33 ‘conventional’ astrocytomas, because of diffuse and strong immunohistochemical coexpression of YKL-40, c-Met, and Cav1. Conclusions: Our findings show that specific morphological traits, such as a granular-cell component, could represent useful features in guiding the search for prognostic and predictive biomarkers that could eventually be therapy-targetable (e.g. Met inhibitors aimed at reducing radioresistance).

AB - Aims: Granular-cell astrocytomas (GCAs) are morphologically characterized by a prominent component of granular periodic acid–Schiff-positive cells, and show increased aggressiveness as compared with ‘ordinary’ astrocytomas. The aim of this study was to investigate, in a small series of three GCAs, the expression of mesenchymal/radioresistance-associated biomarkers [such as chitinase-3-like protein 1 (YKL-40), hepatocyte growth factor receptor (c-Met), and caveolin 1 (Cav1)] that could contribute to the poor outcome associated with this glioma subgroup. Methods and results: Our results show that GCAs, according to the new molecular glioma classifications, consistently show a prognostically negative molecular trait (IDH1wt-ATRX noloss-1p/19q nocodeletion). Furthermore, GCAs significantly differed from a control series of 33 ‘conventional’ astrocytomas, because of diffuse and strong immunohistochemical coexpression of YKL-40, c-Met, and Cav1. Conclusions: Our findings show that specific morphological traits, such as a granular-cell component, could represent useful features in guiding the search for prognostic and predictive biomarkers that could eventually be therapy-targetable (e.g. Met inhibitors aimed at reducing radioresistance).

KW - c-Met

KW - Cav1

KW - granular-cell astrocytoma

KW - granular-cell glioblastoma

KW - YKL-40

UR - http://www.scopus.com/inward/record.url?scp=84978252820&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84978252820&partnerID=8YFLogxK

U2 - 10.1111/his.12944

DO - 10.1111/his.12944

M3 - Article

C2 - 26845757

AN - SCOPUS:84978252820

VL - 69

SP - 329

EP - 337

JO - Histopathology

JF - Histopathology

SN - 0309-0167

IS - 2

ER -