Abstract
Background: The aim of this retrospective study was to investigate the incidence of mesenteric lymph node (MLN) involvement, and its prognostic role in advanced ovarian cancer (OC). Methods: OC patients undergoing rectosigmoid resection during primary debulking surgery or interval debulking surgery were recorded. Progression-free survival (PFS) and overall survival were calculated from the date of diagnosis to the date of relapse/progression, death of disease, or the date of last follow-up. Results: MLNs were detected in 102/148 cases (68.9 %); the rate of MLN involvement was 47.0 %. The percentage of metastatic MLNs was higher in cases with >5 MLNs removed compared with cases with ≤5 MLNs removed (62.7 % vs. 31.3 %; p = 0.0027). A progressive increase in the rate of metastatic MLNs was documented in association with depth of bowel infiltration (p = 0.026). Cases with metastatic MLNs experienced isolated celiac trunk or aortic lymph node recurrences more frequently than patients without MLN involvement (44.8 % vs. 10.7 %; p = 0.0008). PFS did not differ between cases with positive versus negative MLN involvement (2-year PFS = 31 % vs. 43 %; p = 0.58). Conclusion: OC patients undergoing rectosigmoid resection showed metastatic MLN involvement in 47.0 % of cases. Metastatic MLN status is associated with a high rate of isolated aortic and celiac trunk lymph node recurrences.
| Original language | English |
|---|---|
| Pages (from-to) | 2369-2375 |
| Number of pages | 7 |
| Journal | Annals of Surgical Oncology |
| Volume | 21 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 2014 |
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ASJC Scopus subject areas
- Surgery
- Oncology
- Medicine(all)
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Mesenteric lymph node involvement in advanced ovarian cancer patients undergoing rectosigmoid resection : Prognostic role and clinical considerations. / Gallotta, Valerio; Fanfani, Francesco; Fagotti, Anna; Chiantera, Vito; Legge, Francesco; Alletti, Salvatore Gueli; Nero, Camilla; Margariti, Alessandro Pasquale; Papa, Valerio; Alfieri, Sergio; Ciccarone, Francesca; Scambia, Giovanni; Ferrandina, Gabriella.
In: Annals of Surgical Oncology, Vol. 21, No. 7, 2014, p. 2369-2375.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mesenteric lymph node involvement in advanced ovarian cancer patients undergoing rectosigmoid resection
T2 - Prognostic role and clinical considerations
AU - Gallotta, Valerio
AU - Fanfani, Francesco
AU - Fagotti, Anna
AU - Chiantera, Vito
AU - Legge, Francesco
AU - Alletti, Salvatore Gueli
AU - Nero, Camilla
AU - Margariti, Alessandro Pasquale
AU - Papa, Valerio
AU - Alfieri, Sergio
AU - Ciccarone, Francesca
AU - Scambia, Giovanni
AU - Ferrandina, Gabriella
PY - 2014
Y1 - 2014
N2 - Background: The aim of this retrospective study was to investigate the incidence of mesenteric lymph node (MLN) involvement, and its prognostic role in advanced ovarian cancer (OC). Methods: OC patients undergoing rectosigmoid resection during primary debulking surgery or interval debulking surgery were recorded. Progression-free survival (PFS) and overall survival were calculated from the date of diagnosis to the date of relapse/progression, death of disease, or the date of last follow-up. Results: MLNs were detected in 102/148 cases (68.9 %); the rate of MLN involvement was 47.0 %. The percentage of metastatic MLNs was higher in cases with >5 MLNs removed compared with cases with ≤5 MLNs removed (62.7 % vs. 31.3 %; p = 0.0027). A progressive increase in the rate of metastatic MLNs was documented in association with depth of bowel infiltration (p = 0.026). Cases with metastatic MLNs experienced isolated celiac trunk or aortic lymph node recurrences more frequently than patients without MLN involvement (44.8 % vs. 10.7 %; p = 0.0008). PFS did not differ between cases with positive versus negative MLN involvement (2-year PFS = 31 % vs. 43 %; p = 0.58). Conclusion: OC patients undergoing rectosigmoid resection showed metastatic MLN involvement in 47.0 % of cases. Metastatic MLN status is associated with a high rate of isolated aortic and celiac trunk lymph node recurrences.
AB - Background: The aim of this retrospective study was to investigate the incidence of mesenteric lymph node (MLN) involvement, and its prognostic role in advanced ovarian cancer (OC). Methods: OC patients undergoing rectosigmoid resection during primary debulking surgery or interval debulking surgery were recorded. Progression-free survival (PFS) and overall survival were calculated from the date of diagnosis to the date of relapse/progression, death of disease, or the date of last follow-up. Results: MLNs were detected in 102/148 cases (68.9 %); the rate of MLN involvement was 47.0 %. The percentage of metastatic MLNs was higher in cases with >5 MLNs removed compared with cases with ≤5 MLNs removed (62.7 % vs. 31.3 %; p = 0.0027). A progressive increase in the rate of metastatic MLNs was documented in association with depth of bowel infiltration (p = 0.026). Cases with metastatic MLNs experienced isolated celiac trunk or aortic lymph node recurrences more frequently than patients without MLN involvement (44.8 % vs. 10.7 %; p = 0.0008). PFS did not differ between cases with positive versus negative MLN involvement (2-year PFS = 31 % vs. 43 %; p = 0.58). Conclusion: OC patients undergoing rectosigmoid resection showed metastatic MLN involvement in 47.0 % of cases. Metastatic MLN status is associated with a high rate of isolated aortic and celiac trunk lymph node recurrences.
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U2 - 10.1245/s10434-014-3558-0
DO - 10.1245/s10434-014-3558-0
M3 - Article
C2 - 24558070
AN - SCOPUS:84902134130
VL - 21
SP - 2369
EP - 2375
JO - Annals of Surgical Oncology
JF - Annals of Surgical Oncology
SN - 1068-9265
IS - 7
ER -