Mesenteric lymph node involvement in advanced ovarian cancer patients undergoing rectosigmoid resection: Prognostic role and clinical considerations

Valerio Gallotta, Francesco Fanfani, Anna Fagotti, Vito Chiantera, Francesco Legge, Salvatore Gueli Alletti, Camilla Nero, Alessandro Pasquale Margariti, Valerio Papa, Sergio Alfieri, Francesca Ciccarone, Giovanni Scambia, Gabriella Ferrandina

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7 Citations (Scopus)

Abstract

Background: The aim of this retrospective study was to investigate the incidence of mesenteric lymph node (MLN) involvement, and its prognostic role in advanced ovarian cancer (OC). Methods: OC patients undergoing rectosigmoid resection during primary debulking surgery or interval debulking surgery were recorded. Progression-free survival (PFS) and overall survival were calculated from the date of diagnosis to the date of relapse/progression, death of disease, or the date of last follow-up. Results: MLNs were detected in 102/148 cases (68.9 %); the rate of MLN involvement was 47.0 %. The percentage of metastatic MLNs was higher in cases with >5 MLNs removed compared with cases with ≤5 MLNs removed (62.7 % vs. 31.3 %; p = 0.0027). A progressive increase in the rate of metastatic MLNs was documented in association with depth of bowel infiltration (p = 0.026). Cases with metastatic MLNs experienced isolated celiac trunk or aortic lymph node recurrences more frequently than patients without MLN involvement (44.8 % vs. 10.7 %; p = 0.0008). PFS did not differ between cases with positive versus negative MLN involvement (2-year PFS = 31 % vs. 43 %; p = 0.58). Conclusion: OC patients undergoing rectosigmoid resection showed metastatic MLN involvement in 47.0 % of cases. Metastatic MLN status is associated with a high rate of isolated aortic and celiac trunk lymph node recurrences.

Original languageEnglish
Pages (from-to)2369-2375
Number of pages7
JournalAnnals of Surgical Oncology
Volume21
Issue number7
DOIs
Publication statusPublished - 2014

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Ovarian Neoplasms
Lymph Nodes
Disease-Free Survival
Recurrence
Abdomen
Disease Progression
Retrospective Studies
Survival
Incidence

ASJC Scopus subject areas

  • Surgery
  • Oncology
  • Medicine(all)

Cite this

Mesenteric lymph node involvement in advanced ovarian cancer patients undergoing rectosigmoid resection : Prognostic role and clinical considerations. / Gallotta, Valerio; Fanfani, Francesco; Fagotti, Anna; Chiantera, Vito; Legge, Francesco; Alletti, Salvatore Gueli; Nero, Camilla; Margariti, Alessandro Pasquale; Papa, Valerio; Alfieri, Sergio; Ciccarone, Francesca; Scambia, Giovanni; Ferrandina, Gabriella.

In: Annals of Surgical Oncology, Vol. 21, No. 7, 2014, p. 2369-2375.

Research output: Contribution to journalArticle

Gallotta, V, Fanfani, F, Fagotti, A, Chiantera, V, Legge, F, Alletti, SG, Nero, C, Margariti, AP, Papa, V, Alfieri, S, Ciccarone, F, Scambia, G & Ferrandina, G 2014, 'Mesenteric lymph node involvement in advanced ovarian cancer patients undergoing rectosigmoid resection: Prognostic role and clinical considerations', Annals of Surgical Oncology, vol. 21, no. 7, pp. 2369-2375. https://doi.org/10.1245/s10434-014-3558-0
Gallotta, Valerio ; Fanfani, Francesco ; Fagotti, Anna ; Chiantera, Vito ; Legge, Francesco ; Alletti, Salvatore Gueli ; Nero, Camilla ; Margariti, Alessandro Pasquale ; Papa, Valerio ; Alfieri, Sergio ; Ciccarone, Francesca ; Scambia, Giovanni ; Ferrandina, Gabriella. / Mesenteric lymph node involvement in advanced ovarian cancer patients undergoing rectosigmoid resection : Prognostic role and clinical considerations. In: Annals of Surgical Oncology. 2014 ; Vol. 21, No. 7. pp. 2369-2375.
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abstract = "Background: The aim of this retrospective study was to investigate the incidence of mesenteric lymph node (MLN) involvement, and its prognostic role in advanced ovarian cancer (OC). Methods: OC patients undergoing rectosigmoid resection during primary debulking surgery or interval debulking surgery were recorded. Progression-free survival (PFS) and overall survival were calculated from the date of diagnosis to the date of relapse/progression, death of disease, or the date of last follow-up. Results: MLNs were detected in 102/148 cases (68.9 {\%}); the rate of MLN involvement was 47.0 {\%}. The percentage of metastatic MLNs was higher in cases with >5 MLNs removed compared with cases with ≤5 MLNs removed (62.7 {\%} vs. 31.3 {\%}; p = 0.0027). A progressive increase in the rate of metastatic MLNs was documented in association with depth of bowel infiltration (p = 0.026). Cases with metastatic MLNs experienced isolated celiac trunk or aortic lymph node recurrences more frequently than patients without MLN involvement (44.8 {\%} vs. 10.7 {\%}; p = 0.0008). PFS did not differ between cases with positive versus negative MLN involvement (2-year PFS = 31 {\%} vs. 43 {\%}; p = 0.58). Conclusion: OC patients undergoing rectosigmoid resection showed metastatic MLN involvement in 47.0 {\%} of cases. Metastatic MLN status is associated with a high rate of isolated aortic and celiac trunk lymph node recurrences.",
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T1 - Mesenteric lymph node involvement in advanced ovarian cancer patients undergoing rectosigmoid resection

T2 - Prognostic role and clinical considerations

AU - Gallotta, Valerio

AU - Fanfani, Francesco

AU - Fagotti, Anna

AU - Chiantera, Vito

AU - Legge, Francesco

AU - Alletti, Salvatore Gueli

AU - Nero, Camilla

AU - Margariti, Alessandro Pasquale

AU - Papa, Valerio

AU - Alfieri, Sergio

AU - Ciccarone, Francesca

AU - Scambia, Giovanni

AU - Ferrandina, Gabriella

PY - 2014

Y1 - 2014

N2 - Background: The aim of this retrospective study was to investigate the incidence of mesenteric lymph node (MLN) involvement, and its prognostic role in advanced ovarian cancer (OC). Methods: OC patients undergoing rectosigmoid resection during primary debulking surgery or interval debulking surgery were recorded. Progression-free survival (PFS) and overall survival were calculated from the date of diagnosis to the date of relapse/progression, death of disease, or the date of last follow-up. Results: MLNs were detected in 102/148 cases (68.9 %); the rate of MLN involvement was 47.0 %. The percentage of metastatic MLNs was higher in cases with >5 MLNs removed compared with cases with ≤5 MLNs removed (62.7 % vs. 31.3 %; p = 0.0027). A progressive increase in the rate of metastatic MLNs was documented in association with depth of bowel infiltration (p = 0.026). Cases with metastatic MLNs experienced isolated celiac trunk or aortic lymph node recurrences more frequently than patients without MLN involvement (44.8 % vs. 10.7 %; p = 0.0008). PFS did not differ between cases with positive versus negative MLN involvement (2-year PFS = 31 % vs. 43 %; p = 0.58). Conclusion: OC patients undergoing rectosigmoid resection showed metastatic MLN involvement in 47.0 % of cases. Metastatic MLN status is associated with a high rate of isolated aortic and celiac trunk lymph node recurrences.

AB - Background: The aim of this retrospective study was to investigate the incidence of mesenteric lymph node (MLN) involvement, and its prognostic role in advanced ovarian cancer (OC). Methods: OC patients undergoing rectosigmoid resection during primary debulking surgery or interval debulking surgery were recorded. Progression-free survival (PFS) and overall survival were calculated from the date of diagnosis to the date of relapse/progression, death of disease, or the date of last follow-up. Results: MLNs were detected in 102/148 cases (68.9 %); the rate of MLN involvement was 47.0 %. The percentage of metastatic MLNs was higher in cases with >5 MLNs removed compared with cases with ≤5 MLNs removed (62.7 % vs. 31.3 %; p = 0.0027). A progressive increase in the rate of metastatic MLNs was documented in association with depth of bowel infiltration (p = 0.026). Cases with metastatic MLNs experienced isolated celiac trunk or aortic lymph node recurrences more frequently than patients without MLN involvement (44.8 % vs. 10.7 %; p = 0.0008). PFS did not differ between cases with positive versus negative MLN involvement (2-year PFS = 31 % vs. 43 %; p = 0.58). Conclusion: OC patients undergoing rectosigmoid resection showed metastatic MLN involvement in 47.0 % of cases. Metastatic MLN status is associated with a high rate of isolated aortic and celiac trunk lymph node recurrences.

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