Background and Purpose: This study was conducted to evaluate local cerebral blood flow changes in patients with depression after a subcortical stroke. Methods Clinical and neuropsychological assessments were performed in 15 patients with a single subcortical lesion. Depression was assessed by DSM-III-R. In addition, the Hamilton Rating Scale for depression, the Zung Self-Rating Depression Scale, and the Beck scale were administered to each patient. Single-photon emission-computed tomography study was performed with 99mTC hexamethylpropyleneamine oxime. Results In all patients cortical regions ipsilateral to subcortical lesions were significantly less perfused than the contra lateral cortex. Cerebral blood flow values were significantly lower in depressed patients (n=8) than in nondepressed patients (n=7) only in the mesial temporal cortex of the affected hemisphere. Cerebral blood flow values in the mesial temporal cortex of the affected hemisphere significantly correlated with the severity of depression. Conclusions Temporal lobe hypoperfusion may reflect a dysfunction of the limbic system, suggesting that this location may be critical for the occurrence of depressive symptoms in patients with subcortical stroke.
|Number of pages||6|
|Publication status||Published - 1994|
- Subcortical infarction
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Clinical Neurology
- Advanced and Specialised Nursing