Mesial temporal lobe and subcortical grey matter volumes differentially predict memory across stages of multiple sclerosis

JF Sumowski, VM Leavitt, MA Rocca, M Inglese, G Riccitelli, K Buyukturkoglu, Alessandro Meani, M Filippi

Research output: Contribution to journalArticle

Abstract

Background/Objective: Memory deficits due to multiple sclerosis (MS) have been variably linked to lower subcortical grey matter (SCGM) and mesial temporal lobe (MTL) volumes. We investigated which is the better predictor and whether this changes across disease stages. Methods/Results: Memory was assessed in 315 patients. Magnetic resonance imaging (MRI) measured volumes of total brain, grey matter, white matter, MTL (hippocampus, amygdala) and SCGM (thalamus, caudate). MTL predicted memory in the total sample and in patients with earlier ( <10 years) or later (⩾10 years) relapsing disease. SCGM (specifically thalamus) predicted memory in progressive patients. Conclusions: Neuroanatomical correlates of memory deficits differ across disease stages. © 2017, © The Author(s), 2017.
Original languageEnglish
Pages (from-to)675-678
Number of pages4
JournalMultiple Sclerosis Journal
Volume24
Issue number5
DOIs
Publication statusPublished - 2018

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