Mesial temporal sclerosis - A late complication in four allogeneic pediatric recipients with persistent seizures after an acute episode of cyclosporine - A neurotoxicity

M. Faraci, E. Lanino, S. Dallorso, G. Morreale, B. Cappelli, R. Gaggero, G. Dini, R. Haupt, M. P. Fondelli

Research output: Contribution to journalArticle

Abstract

Mesial temporal sclerosis (MTS) is a common finding in patients with intractable temporal lobe epilepsy (TLE). In this report, we retrospectively reviewed the neuroimaging results of four children who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT), and who developed recurrent, partial, intractable seizures following a first event caused by cyclosporine-A (CSA) neurotoxicity. Neuroradiologic findings of MTS were demonstrated in all these patients. We suggest that MTS may be a consequence of CSA neurotoxicity, which induces repeated seizures, associated with other predisposing conditions, as well as being a consequence of the underlying disease and its treatment, and of severe graft-versus-host disease (GvHD).

Original languageEnglish
Pages (from-to)919-922
Number of pages4
JournalBone Marrow Transplantation
Volume31
Issue number10
DOIs
Publication statusPublished - May 2003

Keywords

  • Cyclosporine neurotoxicity
  • Intractable temporal epilepsy
  • Mesial temporal sclerosis

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Fingerprint Dive into the research topics of 'Mesial temporal sclerosis - A late complication in four allogeneic pediatric recipients with persistent seizures after an acute episode of cyclosporine - A neurotoxicity'. Together they form a unique fingerprint.

  • Cite this