Mesiobasal versus lateral temporal lobe epilepsy

Metabolic differences in the temporal lobe shown by interictal 18F-FDG positron emission tomography

Marketa Hajek, Angelo Antonini, Klaus Leonhard Leenders, Heinz Gregor Wieser

Research output: Contribution to journalArticle

144 Citations (Scopus)

Abstract

Metabolic abnormalities in the temporal lobe (TL) of 25 patients suffering from temporal lobe epilepsy of mesiobasal or lateral TL origin have been investigated using interjetai [18F]-fluorodeoxyglucose (FDG) positron emission tomography (PET). The epileptogenic area was determined by ictal EEG recordings using foramen ovale and scalp electrodes in 20 patients, and by the use of stereo-electroencephalography in one patient. Four patients with structural lesions on their MRIs had noninvasive ictal surface EEG recordings. Sixteen patients had a clear-cut mesiobasal seizure onset, and in five patients the seizures originated from the lateral temporal neocortex. Twenty-four patients underwent selective surgery. Patients with temporal limbic seizures associated with mesial gliosis (n = 15) had the lowest FDG uptake in the entire TL, followed by patients with lateral temporal seizure origin (n = 5). Patients with tumors located in the mesiobasal TL (n = 5) showed, in general, only a slight decrease of glucose metabolism in all TL structures. There was no clear-cut correlation between the degree of hypometabolism and the location of EEG-defined epileptogenic focus. The metabolic pattern, however, differed between the patient groups and allowed a discrimination between patients of mesial temporal and lateral temporal seizure onset.

Original languageEnglish
Pages (from-to)79-86
Number of pages8
JournalNeurology
Volume43
Issue number1
Publication statusPublished - Jan 1993

Fingerprint

Temporal Lobe Epilepsy
Fluorodeoxyglucose F18
Temporal Lobe
Positron-Emission Tomography
Seizures
Electroencephalography
Stroke
Foramen Ovale
Gliosis
Neocortex
Scalp
Electrodes

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Mesiobasal versus lateral temporal lobe epilepsy : Metabolic differences in the temporal lobe shown by interictal 18F-FDG positron emission tomography. / Hajek, Marketa; Antonini, Angelo; Leenders, Klaus Leonhard; Wieser, Heinz Gregor.

In: Neurology, Vol. 43, No. 1, 01.1993, p. 79-86.

Research output: Contribution to journalArticle

Hajek, Marketa ; Antonini, Angelo ; Leenders, Klaus Leonhard ; Wieser, Heinz Gregor. / Mesiobasal versus lateral temporal lobe epilepsy : Metabolic differences in the temporal lobe shown by interictal 18F-FDG positron emission tomography. In: Neurology. 1993 ; Vol. 43, No. 1. pp. 79-86.
@article{3811d33f39714bb698a9833d57be607d,
title = "Mesiobasal versus lateral temporal lobe epilepsy: Metabolic differences in the temporal lobe shown by interictal 18F-FDG positron emission tomography",
abstract = "Metabolic abnormalities in the temporal lobe (TL) of 25 patients suffering from temporal lobe epilepsy of mesiobasal or lateral TL origin have been investigated using interjetai [18F]-fluorodeoxyglucose (FDG) positron emission tomography (PET). The epileptogenic area was determined by ictal EEG recordings using foramen ovale and scalp electrodes in 20 patients, and by the use of stereo-electroencephalography in one patient. Four patients with structural lesions on their MRIs had noninvasive ictal surface EEG recordings. Sixteen patients had a clear-cut mesiobasal seizure onset, and in five patients the seizures originated from the lateral temporal neocortex. Twenty-four patients underwent selective surgery. Patients with temporal limbic seizures associated with mesial gliosis (n = 15) had the lowest FDG uptake in the entire TL, followed by patients with lateral temporal seizure origin (n = 5). Patients with tumors located in the mesiobasal TL (n = 5) showed, in general, only a slight decrease of glucose metabolism in all TL structures. There was no clear-cut correlation between the degree of hypometabolism and the location of EEG-defined epileptogenic focus. The metabolic pattern, however, differed between the patient groups and allowed a discrimination between patients of mesial temporal and lateral temporal seizure onset.",
author = "Marketa Hajek and Angelo Antonini and Leenders, {Klaus Leonhard} and Wieser, {Heinz Gregor}",
year = "1993",
month = "1",
language = "English",
volume = "43",
pages = "79--86",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Mesiobasal versus lateral temporal lobe epilepsy

T2 - Metabolic differences in the temporal lobe shown by interictal 18F-FDG positron emission tomography

AU - Hajek, Marketa

AU - Antonini, Angelo

AU - Leenders, Klaus Leonhard

AU - Wieser, Heinz Gregor

PY - 1993/1

Y1 - 1993/1

N2 - Metabolic abnormalities in the temporal lobe (TL) of 25 patients suffering from temporal lobe epilepsy of mesiobasal or lateral TL origin have been investigated using interjetai [18F]-fluorodeoxyglucose (FDG) positron emission tomography (PET). The epileptogenic area was determined by ictal EEG recordings using foramen ovale and scalp electrodes in 20 patients, and by the use of stereo-electroencephalography in one patient. Four patients with structural lesions on their MRIs had noninvasive ictal surface EEG recordings. Sixteen patients had a clear-cut mesiobasal seizure onset, and in five patients the seizures originated from the lateral temporal neocortex. Twenty-four patients underwent selective surgery. Patients with temporal limbic seizures associated with mesial gliosis (n = 15) had the lowest FDG uptake in the entire TL, followed by patients with lateral temporal seizure origin (n = 5). Patients with tumors located in the mesiobasal TL (n = 5) showed, in general, only a slight decrease of glucose metabolism in all TL structures. There was no clear-cut correlation between the degree of hypometabolism and the location of EEG-defined epileptogenic focus. The metabolic pattern, however, differed between the patient groups and allowed a discrimination between patients of mesial temporal and lateral temporal seizure onset.

AB - Metabolic abnormalities in the temporal lobe (TL) of 25 patients suffering from temporal lobe epilepsy of mesiobasal or lateral TL origin have been investigated using interjetai [18F]-fluorodeoxyglucose (FDG) positron emission tomography (PET). The epileptogenic area was determined by ictal EEG recordings using foramen ovale and scalp electrodes in 20 patients, and by the use of stereo-electroencephalography in one patient. Four patients with structural lesions on their MRIs had noninvasive ictal surface EEG recordings. Sixteen patients had a clear-cut mesiobasal seizure onset, and in five patients the seizures originated from the lateral temporal neocortex. Twenty-four patients underwent selective surgery. Patients with temporal limbic seizures associated with mesial gliosis (n = 15) had the lowest FDG uptake in the entire TL, followed by patients with lateral temporal seizure origin (n = 5). Patients with tumors located in the mesiobasal TL (n = 5) showed, in general, only a slight decrease of glucose metabolism in all TL structures. There was no clear-cut correlation between the degree of hypometabolism and the location of EEG-defined epileptogenic focus. The metabolic pattern, however, differed between the patient groups and allowed a discrimination between patients of mesial temporal and lateral temporal seizure onset.

UR - http://www.scopus.com/inward/record.url?scp=0027393266&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027393266&partnerID=8YFLogxK

M3 - Article

VL - 43

SP - 79

EP - 86

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 1

ER -