Mesoporous bioactive glass as a multifunctional system for bone regeneration and controlled drug release

Francesco Baino, Sonia Fiorilli, Renato Mortera, Barbara Onida, Enrica Saino, Livia Visai, Enrica Verné, Chiara Vitale-Brovarone

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Purpose: Coupling the potential for bone regeneration and the ability for in situ controlled drug release in a single device is a challenging field of research in bone tissue engineering; in an attempt to pursue this aim, mesoporous bioactive glass (MBG) membranes belonging to the SiO2-P2O5-CaO ternary system were produced and characterized. Methods: The glass was synthesized via a sol-gel route coupled with an evaporation-induced self-assembly process by using a non-ionic block co-polymer as a mesostructure former. MBG structure and morphology, as well as mesopores size and shape, were investigated by x-ray diffraction, transmission electron microscopy, and N2 adsorption-desorption measurements. In vitro bioactivity was investigated by soaking MBG membranes in simulated body fluid (SBF) for different time frames. Ibuprofen was encapsulated into MBG pores and drug release kinetics in SBF were assessed. Biological tests by using SAOS-2 cells were performed to assess the material cytocompatibility. Results: The material revealed significant ability to induce hydroxyapatite formation on its surface (bioactivity). Drug release kinetics in SBF are very similar to those obtained for mesoporous silica having mesopore size comparable to that of the prepared MBG (~5 nm). No evidence of cell viability depression was detected during in vitro culture, which demonstrates the good biological compatibility of the material. Conclusions: The easiness of tailoring and shaping, the highly bioactive and biocompatible behavior, and the drug uptake/ release ability of the prepared materials may suggest their use as "smart" multifunctional grafts for bone reconstructive surgery.

Original languageEnglish
Pages (from-to)11-20
Number of pages10
JournalJournal of Applied Biomaterials and Functional Materials
Volume10
Issue number1
DOIs
Publication statusPublished - 2012

Fingerprint

Bioactive glass
Bone Regeneration
Glass
Bone
Body fluids
Body Fluids
phosphorus pentoxide
Pharmaceutical Preparations
Bioactivity
Reconstructive Surgical Procedures
Membranes
Pharmacokinetics
Kinetics
Ibuprofen
Bone and Bones
Ternary systems
Durapatite
Hydroxyapatite
Tissue engineering
Cell culture

Keywords

  • Bioactivity
  • Biocompatibility
  • Bone grafting
  • Drug release
  • Mesoporous glasses
  • Tissue engineering

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomedical Engineering
  • Biomaterials

Cite this

Mesoporous bioactive glass as a multifunctional system for bone regeneration and controlled drug release. / Baino, Francesco; Fiorilli, Sonia; Mortera, Renato; Onida, Barbara; Saino, Enrica; Visai, Livia; Verné, Enrica; Vitale-Brovarone, Chiara.

In: Journal of Applied Biomaterials and Functional Materials, Vol. 10, No. 1, 2012, p. 11-20.

Research output: Contribution to journalArticle

Baino, Francesco ; Fiorilli, Sonia ; Mortera, Renato ; Onida, Barbara ; Saino, Enrica ; Visai, Livia ; Verné, Enrica ; Vitale-Brovarone, Chiara. / Mesoporous bioactive glass as a multifunctional system for bone regeneration and controlled drug release. In: Journal of Applied Biomaterials and Functional Materials. 2012 ; Vol. 10, No. 1. pp. 11-20.
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