Abstract
We studied rats with a hemi-Parkinsonian model created by lesions of mesostriatal dopaminergic neurons. Correlation between the extent of lesions and intensity of forced rotation movements (apomorphine (APO)-induced rotations, i.e., exercise) was investigated. The levels of endothelins (ET) in the circulation after rotation under normoxic and hypoxic conditions were measured. In normoxia, the rotation sessions were associated with significant decreases in circulating ET levels, from 21.32 ± 4.06 to 9.32 ± 1.08 pg/ml. Although hypoxia had no effect on the frequency of rotations induced by APO, it significantly attenuated a decrease in the ET levels in the circulation of rats with the most extensive lesions. We suggest that the mesostriatal dopaminergic system modulates endothelial function by an active process. This may have relevance for some clinical manifestations of disordered striatal function observed in humans.
| Original language | English |
|---|---|
| Pages (from-to) | 13-18 |
| Number of pages | 6 |
| Journal | Neurophysiology |
| Volume | 30 |
| Issue number | 1 |
| Publication status | Published - Jan 1998 |
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ASJC Scopus subject areas
- Neuroscience(all)
- Physiology
Cite this
Mesostriatal lesions and endothelial function : Effects of forced movements and hypoxia on levels of circulating endothelins. / Sagach, V. F.; Bazilyuk, O. V.; Oleshko, N. N.; Maiskii, V. A.; Costa, A.; Martignoni, E.; Qualls, C.; Appenzeller, O.
In: Neurophysiology, Vol. 30, No. 1, 01.1998, p. 13-18.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mesostriatal lesions and endothelial function
T2 - Effects of forced movements and hypoxia on levels of circulating endothelins
AU - Sagach, V. F.
AU - Bazilyuk, O. V.
AU - Oleshko, N. N.
AU - Maiskii, V. A.
AU - Costa, A.
AU - Martignoni, E.
AU - Qualls, C.
AU - Appenzeller, O.
PY - 1998/1
Y1 - 1998/1
N2 - We studied rats with a hemi-Parkinsonian model created by lesions of mesostriatal dopaminergic neurons. Correlation between the extent of lesions and intensity of forced rotation movements (apomorphine (APO)-induced rotations, i.e., exercise) was investigated. The levels of endothelins (ET) in the circulation after rotation under normoxic and hypoxic conditions were measured. In normoxia, the rotation sessions were associated with significant decreases in circulating ET levels, from 21.32 ± 4.06 to 9.32 ± 1.08 pg/ml. Although hypoxia had no effect on the frequency of rotations induced by APO, it significantly attenuated a decrease in the ET levels in the circulation of rats with the most extensive lesions. We suggest that the mesostriatal dopaminergic system modulates endothelial function by an active process. This may have relevance for some clinical manifestations of disordered striatal function observed in humans.
AB - We studied rats with a hemi-Parkinsonian model created by lesions of mesostriatal dopaminergic neurons. Correlation between the extent of lesions and intensity of forced rotation movements (apomorphine (APO)-induced rotations, i.e., exercise) was investigated. The levels of endothelins (ET) in the circulation after rotation under normoxic and hypoxic conditions were measured. In normoxia, the rotation sessions were associated with significant decreases in circulating ET levels, from 21.32 ± 4.06 to 9.32 ± 1.08 pg/ml. Although hypoxia had no effect on the frequency of rotations induced by APO, it significantly attenuated a decrease in the ET levels in the circulation of rats with the most extensive lesions. We suggest that the mesostriatal dopaminergic system modulates endothelial function by an active process. This may have relevance for some clinical manifestations of disordered striatal function observed in humans.
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UR - http://www.scopus.com/inward/citedby.url?scp=0008179834&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0008179834
VL - 30
SP - 13
EP - 18
JO - Neurophysiology
JF - Neurophysiology
SN - 0090-2977
IS - 1
ER -