Mesostriatal lesions and endothelial function: Effects of forced movements and hypoxia on levels of circulating endothelins

V. F. Sagach, O. V. Bazilyuk, N. N. Oleshko, V. A. Maiskii, A. Costa, E. Martignoni, C. Qualls, O. Appenzeller

Research output: Contribution to journalArticlepeer-review

Abstract

We studied rats with a hemi-Parkinsonian model created by lesions of mesostriatal dopaminergic neurons. Correlation between the extent of lesions and intensity of forced rotation movements (apomorphine (APO)-induced rotations, i.e., exercise) was investigated. The levels of endothelins (ET) in the circulation after rotation under normoxic and hypoxic conditions were measured. In normoxia, the rotation sessions were associated with significant decreases in circulating ET levels, from 21.32 ± 4.06 to 9.32 ± 1.08 pg/ml. Although hypoxia had no effect on the frequency of rotations induced by APO, it significantly attenuated a decrease in the ET levels in the circulation of rats with the most extensive lesions. We suggest that the mesostriatal dopaminergic system modulates endothelial function by an active process. This may have relevance for some clinical manifestations of disordered striatal function observed in humans.

Original languageEnglish
Pages (from-to)13-18
Number of pages6
JournalNeurophysiology
Volume30
Issue number1
Publication statusPublished - Jan 1998

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology

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