Mesothelin in serum and pleural effusion in the diagnosis of malignant pleural Mesothelioma with non-positive cytology

Maria Cristiana Franceschini, Paola Ferro, Pier Aldo Canessa, Enrico Battolla, Paolo Dessanti, Alessandro Valentino, Laura Casolari, Vincenzo Fontana, Riccardo Pezzi, Franco Fedeli, Maria Pia Pistillo, Silvio Roncella

Research output: Contribution to journalArticlepeer-review

Abstract

Background/Aim: Mesothelin (SMRP) is regarded as a biomarker of malignant pleural mesothelioma (MPM). Herein, we analyzed the contribution of SMRP detection in pleural effusion and in serum to the diagnosis of MPM with non-positive cytology. Materials and Methods: The present study included 52 cases of MPM, 43 of pleural benign lesions and 25 of non-MPM pleural metastases. SMRP was measured by MesoMark ELISA (Cis-Bio International Gif/Yvette; France). Results: In non-positive cytology, effusion-SMRP showed higher diagnostic performance than serum-SMRP. We found 38 out of 52 (73.1%) cases of non-positive cytology MPM, out of which 27 (71.0%) were positive for effusion-SMRP (cut-off=12.70 nM) and 18 (47.4%) for serum-SMRP (cut-off=1.08 nM). When cytology, effusion- and serum-SMRP were used in combination, an overall sensitivity in detection of MPM of 78.9% was achieved. The same sensitivity was obtained by combining cytology with effusion-SMRP alone, whereas the combination of serum-SMRP with cytology led to a sensitivity of 61.5%. Conclusion: Detection of both effusion- and serum-SMRP can contribute to improve the diagnosis of MPM with non-positive cytology. However, the analysis of SMRP in effusion makes it unnecessary to test SMRP in the serum.

Original languageEnglish
Pages (from-to)7425-7429
Number of pages5
JournalAnticancer Research
Volume34
Issue number12
Publication statusPublished - Dec 1 2014

Keywords

  • Cytology
  • Malignant pleural effusion
  • Mesomark assay
  • Mesothelin
  • Mesothelioma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

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