Mesothelin is more useful in pleural effusion than in serum in the diagnosis of pleural mesothelioma

Paola Ferro, Pier Aldo Canessa, Enrico Battolla, Paolo Dessanti, Maria Cristiana Franceschini, Luigi Chiaffi, Anna Morabito, Vincenzo Fontana, Riccardo Pezzi, Franco Fedeli, Maria Pia Pistillo, Silvio Roncella

Research output: Contribution to journalArticlepeer-review


Background/Aim: Soluble mesothelin-related peptide (SMRP) is regarded as a biomarker of malignant pleural mesothelioma (MPM). Herein, we compared the diagnostic performances of SMRP in matched pleural effusion (PE-SMRP) and serum (S-SMRP). Materials and Methods: Diagnosis on pleural biopsies was performed for all patients including 43 with MPM, 23 with non-MPM pleural metastases (MTS) and 36 with benign (BNG) pleural diseases. SMRP was measured by a MesoMark ELISA (Cis-Bio International Gif/Yvette; France). Results: Using the receiver operating characteristic (ROC) analysis, 12.70 and 1.08 nM were detected as cut-off values to optimal discrimination for PESMRP and S-SMRP, respectively. PE-SMRP showed a better diagnostic accuracy than S-SMRP in MPM vs. MTS+BNG (area under the ROC curve=81.6 vs. 70.5; sensitivity=69.8% vs. 46.5%; specificity=88.1% vs. 84.7%; diagnostic odds ratio (DOR)=17.1 vs. 4.8). In S-SMRP-negative patients, PE-SMRP maintained an acceptable performance (Sensitivity=47.8%; DOR=8.3; p=0.001), whereas in PE-SMRP-negative patients, S-SMRP performed very poorly (Sensitivity=15.4%; DOR=1.2; p=0.858). Conclusion: PE-SMRP detection has a superior diagnostic accuracy than S-SMRP detection in the diagnosis of MPM.

Original languageEnglish
Pages (from-to)2707-2714
Number of pages8
JournalAnticancer Research
Issue number6
Publication statusPublished - Jun 2013


  • Malignant pleural effusion
  • Mesomark assay
  • Mesothelin
  • Pleural mesothelioma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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