MET and small-cell lung cancer

Francesco Gelsomino, Giulio Rossi, Marcello Tiseo

Research output: Contribution to journalArticlepeer-review

Abstract

Small-cell lung cancer (SCLC) is one of the most aggressive lung tumors. The majority of patients with SCLC are diagnosed at an advanced stage. This tumor type is highly sensitive to chemo-radiation treatment, with very high response rates, but invariably relapses. At this time, treatment options are still limited and the prognosis of these patients is poor. A better knowledge of the molecular biology of SCLC allowed us to identify potential druggable targets. Among these, the MET/HGF axis seems to be one of the most aberrant signaling pathways involved in SCLC invasiveness and progression. In this review, we describe briefly all recent literature on the different molecular profiling in SCLC; in particular, we discuss the specific alterations involving c-MET gene and their implications as a potential target in SCLC.

Original languageEnglish
Pages (from-to)2100-2115
Number of pages16
JournalCancers
Volume6
Issue number4
DOIs
Publication statusPublished - Oct 13 2014

Keywords

  • c-MET
  • c-MET signaling pathway
  • Mutations
  • Small-cell lung cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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