MET signalling: Principles and functions in development, organ regeneration and cancer

Livio Trusolino, Andrea Bertotti, Paolo M. Comoglio

Research output: Contribution to journalArticle

Abstract

The MET tyrosine kinase receptor (also known as the HGF receptor) promotes tissue remodelling, which underlies developmental morphogenesis, wound repair, organ homeostasis and cancer metastasis, by integrating growth, survival and migration cues in response to environmental stimuli or cell-autonomous perturbations. The versatility of MET-mediated biological responses is sustained by qualitative and quantitative signal modulation. Qualitative mechanisms include the engagement of dedicated signal transducers and the subcellular compartmentalization of MET signalling pathways, whereas quantitative regulation involves MET partnering with adaptor amplifiers or being degraded through the shedding of its extracellular domain or through intracellular ubiquitylation. Controlled activation of MET signalling can be exploited in regenerative medicine, whereas MET inhibition might slow down tumour progression.

Original languageEnglish
Pages (from-to)834-848
Number of pages15
JournalNature Reviews Molecular Cell Biology
Volume11
Issue number12
DOIs
Publication statusPublished - Dec 2010

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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