TY - JOUR
T1 - Meta-analyses
T2 - First-rank evidence or second-hand information?
AU - Zanchetti, Alberto
PY - 2011/5
Y1 - 2011/5
N2 - On the basis of a meta-analysis of randomized studies assessing reductions in 24 h ambulatory blood pressure, investigators have concluded that hydrochlorothiazide is an inappropriate first-line drug for antihypertensive treatment. This conclusion has the potential to change current prescribing practice for patients with hypertension, but should meta-analyses be considered the ultimate level of evidence, particularly those based on a surrogate outcome?
AB - On the basis of a meta-analysis of randomized studies assessing reductions in 24 h ambulatory blood pressure, investigators have concluded that hydrochlorothiazide is an inappropriate first-line drug for antihypertensive treatment. This conclusion has the potential to change current prescribing practice for patients with hypertension, but should meta-analyses be considered the ultimate level of evidence, particularly those based on a surrogate outcome?
UR - http://www.scopus.com/inward/record.url?scp=79955482432&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79955482432&partnerID=8YFLogxK
U2 - 10.1038/nrcardio.2011.39
DO - 10.1038/nrcardio.2011.39
M3 - Article
C2 - 21423247
AN - SCOPUS:79955482432
VL - 8
SP - 249
EP - 251
JO - Nature Reviews Cardiology
JF - Nature Reviews Cardiology
SN - 1759-5002
IS - 5
ER -