Meta-analyses: First-rank evidence or second-hand information?

Alberto Zanchetti

Research output: Contribution to journalArticlepeer-review


On the basis of a meta-analysis of randomized studies assessing reductions in 24 h ambulatory blood pressure, investigators have concluded that hydrochlorothiazide is an inappropriate first-line drug for antihypertensive treatment. This conclusion has the potential to change current prescribing practice for patients with hypertension, but should meta-analyses be considered the ultimate level of evidence, particularly those based on a surrogate outcome?

Original languageEnglish
Pages (from-to)249-251
Number of pages3
JournalNature Reviews Cardiology
Issue number5
Publication statusPublished - May 2011

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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