Meta-analyses of the methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and risk of head and neck and lung cancer

Stefania Boccia, Paolo Boffetta, Paul Brennan, Gualtiero Ricciardi, Francesco Gianfagna, Keitaro Matsuo, Cornelia M van Duijn, Rayjean J. Hung

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Authors report the results of four meta-analyses of studies that examined the association between methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms and head and neck cancer (nine studies, 2076 cases and 4834 controls for C677T; four studies, 1439 cases and 3941 controls for A1298C), and lung cancer (ten studies, 5274 cases and 7435 controls for C677T; seven studies, 5098 cases and 6243 controls for A1298C). The summary odds ratio (OR) of head and neck cancer was 0.92 (95% CI: 0.76-1.11) for MTHFR 677 TT and 0.68 (95% CI: 0.37-1.26) for MTHFR 1298 CC. The OR of lung cancer was 1.22 [95% confidence interval (CI): 0.95-1.55] for MTHFR 677 TT and 1.07 (95% CI: 0.83-1.38) for MTHFR 1298 CC. Results from the meta-analysis of three studies on C677T stratified according to dietary folate intake showed an increased risk for individuals with low folate intake (OR = 1.37, 95% CI: 0.92-2.06 for head and neck and OR = 1.28, 95% CI: 0.97-1.68 for lung) versus high folate intake (OR = 0.85, 95% CI: 0.63-1.16 for head and neck, and OR = 0.94, 95% CI: 0.79-1.12 for lung). Despite the lack of formal statistical significance, these findings are consistent with the hypothesis that folate play a role in lung and head/neck carcinogenesis, and show the need to incorporate data on folate intake when interpreting results of MTHFR polymorphisms in relation to cancer risk.

Original languageEnglish
Pages (from-to)55-61
Number of pages7
JournalCancer Letters
Volume273
Issue number1
DOIs
Publication statusPublished - Jan 8 2009

Fingerprint

Methylenetetrahydrofolate Reductase (NADPH2)
Head and Neck Neoplasms
Meta-Analysis
Lung Neoplasms
Confidence Intervals
Folic Acid
Odds Ratio
Neck
Head
Lung
Carcinogenesis

Keywords

  • Genetic susceptibility
  • Head and neck cancer
  • Lung cancer
  • Meta-analysis
  • Methylenetetrahydrofolate reductase (MTHFR)

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Meta-analyses of the methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and risk of head and neck and lung cancer. / Boccia, Stefania; Boffetta, Paolo; Brennan, Paul; Ricciardi, Gualtiero; Gianfagna, Francesco; Matsuo, Keitaro; Duijn, Cornelia M van; Hung, Rayjean J.

In: Cancer Letters, Vol. 273, No. 1, 08.01.2009, p. 55-61.

Research output: Contribution to journalArticle

Boccia, Stefania ; Boffetta, Paolo ; Brennan, Paul ; Ricciardi, Gualtiero ; Gianfagna, Francesco ; Matsuo, Keitaro ; Duijn, Cornelia M van ; Hung, Rayjean J. / Meta-analyses of the methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and risk of head and neck and lung cancer. In: Cancer Letters. 2009 ; Vol. 273, No. 1. pp. 55-61.
@article{5982ea2f94fd4bf182f92230a6dcc26a,
title = "Meta-analyses of the methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and risk of head and neck and lung cancer",
abstract = "Authors report the results of four meta-analyses of studies that examined the association between methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms and head and neck cancer (nine studies, 2076 cases and 4834 controls for C677T; four studies, 1439 cases and 3941 controls for A1298C), and lung cancer (ten studies, 5274 cases and 7435 controls for C677T; seven studies, 5098 cases and 6243 controls for A1298C). The summary odds ratio (OR) of head and neck cancer was 0.92 (95{\%} CI: 0.76-1.11) for MTHFR 677 TT and 0.68 (95{\%} CI: 0.37-1.26) for MTHFR 1298 CC. The OR of lung cancer was 1.22 [95{\%} confidence interval (CI): 0.95-1.55] for MTHFR 677 TT and 1.07 (95{\%} CI: 0.83-1.38) for MTHFR 1298 CC. Results from the meta-analysis of three studies on C677T stratified according to dietary folate intake showed an increased risk for individuals with low folate intake (OR = 1.37, 95{\%} CI: 0.92-2.06 for head and neck and OR = 1.28, 95{\%} CI: 0.97-1.68 for lung) versus high folate intake (OR = 0.85, 95{\%} CI: 0.63-1.16 for head and neck, and OR = 0.94, 95{\%} CI: 0.79-1.12 for lung). Despite the lack of formal statistical significance, these findings are consistent with the hypothesis that folate play a role in lung and head/neck carcinogenesis, and show the need to incorporate data on folate intake when interpreting results of MTHFR polymorphisms in relation to cancer risk.",
keywords = "Genetic susceptibility, Head and neck cancer, Lung cancer, Meta-analysis, Methylenetetrahydrofolate reductase (MTHFR)",
author = "Stefania Boccia and Paolo Boffetta and Paul Brennan and Gualtiero Ricciardi and Francesco Gianfagna and Keitaro Matsuo and Duijn, {Cornelia M van} and Hung, {Rayjean J.}",
year = "2009",
month = "1",
day = "8",
doi = "10.1016/j.canlet.2008.07.026",
language = "English",
volume = "273",
pages = "55--61",
journal = "Cancer Letters",
issn = "0304-3835",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

TY - JOUR

T1 - Meta-analyses of the methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and risk of head and neck and lung cancer

AU - Boccia, Stefania

AU - Boffetta, Paolo

AU - Brennan, Paul

AU - Ricciardi, Gualtiero

AU - Gianfagna, Francesco

AU - Matsuo, Keitaro

AU - Duijn, Cornelia M van

AU - Hung, Rayjean J.

PY - 2009/1/8

Y1 - 2009/1/8

N2 - Authors report the results of four meta-analyses of studies that examined the association between methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms and head and neck cancer (nine studies, 2076 cases and 4834 controls for C677T; four studies, 1439 cases and 3941 controls for A1298C), and lung cancer (ten studies, 5274 cases and 7435 controls for C677T; seven studies, 5098 cases and 6243 controls for A1298C). The summary odds ratio (OR) of head and neck cancer was 0.92 (95% CI: 0.76-1.11) for MTHFR 677 TT and 0.68 (95% CI: 0.37-1.26) for MTHFR 1298 CC. The OR of lung cancer was 1.22 [95% confidence interval (CI): 0.95-1.55] for MTHFR 677 TT and 1.07 (95% CI: 0.83-1.38) for MTHFR 1298 CC. Results from the meta-analysis of three studies on C677T stratified according to dietary folate intake showed an increased risk for individuals with low folate intake (OR = 1.37, 95% CI: 0.92-2.06 for head and neck and OR = 1.28, 95% CI: 0.97-1.68 for lung) versus high folate intake (OR = 0.85, 95% CI: 0.63-1.16 for head and neck, and OR = 0.94, 95% CI: 0.79-1.12 for lung). Despite the lack of formal statistical significance, these findings are consistent with the hypothesis that folate play a role in lung and head/neck carcinogenesis, and show the need to incorporate data on folate intake when interpreting results of MTHFR polymorphisms in relation to cancer risk.

AB - Authors report the results of four meta-analyses of studies that examined the association between methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms and head and neck cancer (nine studies, 2076 cases and 4834 controls for C677T; four studies, 1439 cases and 3941 controls for A1298C), and lung cancer (ten studies, 5274 cases and 7435 controls for C677T; seven studies, 5098 cases and 6243 controls for A1298C). The summary odds ratio (OR) of head and neck cancer was 0.92 (95% CI: 0.76-1.11) for MTHFR 677 TT and 0.68 (95% CI: 0.37-1.26) for MTHFR 1298 CC. The OR of lung cancer was 1.22 [95% confidence interval (CI): 0.95-1.55] for MTHFR 677 TT and 1.07 (95% CI: 0.83-1.38) for MTHFR 1298 CC. Results from the meta-analysis of three studies on C677T stratified according to dietary folate intake showed an increased risk for individuals with low folate intake (OR = 1.37, 95% CI: 0.92-2.06 for head and neck and OR = 1.28, 95% CI: 0.97-1.68 for lung) versus high folate intake (OR = 0.85, 95% CI: 0.63-1.16 for head and neck, and OR = 0.94, 95% CI: 0.79-1.12 for lung). Despite the lack of formal statistical significance, these findings are consistent with the hypothesis that folate play a role in lung and head/neck carcinogenesis, and show the need to incorporate data on folate intake when interpreting results of MTHFR polymorphisms in relation to cancer risk.

KW - Genetic susceptibility

KW - Head and neck cancer

KW - Lung cancer

KW - Meta-analysis

KW - Methylenetetrahydrofolate reductase (MTHFR)

UR - http://www.scopus.com/inward/record.url?scp=56349130046&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=56349130046&partnerID=8YFLogxK

U2 - 10.1016/j.canlet.2008.07.026

DO - 10.1016/j.canlet.2008.07.026

M3 - Article

C2 - 18789576

AN - SCOPUS:56349130046

VL - 273

SP - 55

EP - 61

JO - Cancer Letters

JF - Cancer Letters

SN - 0304-3835

IS - 1

ER -