Meta-analysis and pooled analysis of GSTM1 and CYP1A1 polymorphisms and oral and pharyngeal cancers: A HuGE-GSEC review

Leonor Varela-Lema, Emanuela Taioli, Alberto Ruano-Ravina, Juan M. Barros-Dios, Devasena Anantharaman, Simone Benhamou, Stefania Boccia, Rajani A. Bhisey, Gabriella Cadoni, Ettore Capoluongo, Chien Jen Chen, William D. Foulkes, Eny Maria Goloni-Bertollo, Ana Hatagima, Richard B. Hayes, Takahiko Katoh, Sergio Koifman, Phillip Lazarus, Johannes J. Manni, Manoj MahimkarShunji Morita, Jong Park, Kwang Kyun Park, Erika Cristina Pavarino Bertelli, Enilze Maria De Souza Fonseca Ribeiro, Bidyut Roy, Margaret R. Spitz, Richard C. Strange, Qingyi Wei, Camille C. Ragin

Research output: Contribution to journalArticlepeer-review

Abstract

The association of GSTM1 and CYP1A1 polymorphisms and oral and pharyngeal cancers was assessed through a meta-analysis of published case-control studies and a pooled analysis of both published and unpublished case-control studies from the Genetic Susceptibility to Environmental Carcinogens database (http://www.upci.upmc.edu/research/ccps/ccontrol/index.html). Thirty publications used in the meta-analysis included a total of 7783 subjects (3177 cases and 4606 controls); 21 datasets, 9397 subjects (3130 cases and 6267 controls) were included in the pooled analysis. The GSTM1 deletion was 2-fold more likely to occur in African American and African cases than controls (odds ratio: 1.7, 95% confidence interval: 0.9-3.3), although this was not observed among whites (odds ratio: 1.0, 95% confidence interval: 0.9-1.1). The meta-analysis and pooled analysis showed a significant association between oral and pharyngeal cancer and the CYP1A1 MspI homozygous variant (meta-ORm2/m2: 1.9, 95% confidence interval: 1.4-2.7; Pooled ORm2m2: 2.0, 95% confidence interval: 1.3-3.1; ORm1m2 or [infi]m2m2: 1.3, 95% confidence interval: 1.1-1.6). The association was present for the CYP1A1 (exon 7) polymorphism (ORVal/Val: 2.2, 95% confidence interval: 1.1-4.5) in ever smokers. A joint effect was observed for GSTM1 homozygous deletion and the CYP1A1 m1m2 variant on cancer risk. Our findings suggest that tobacco use and genetic factors play a significant role in oral and pharyngeal cancer.

Original languageEnglish
Pages (from-to)369-384
Number of pages16
JournalGenetics in Medicine
Volume10
Issue number6
DOIs
Publication statusPublished - Jun 2008

Keywords

  • CYP1A1
  • Epidemiology
  • GSTM1
  • Meta-analysis and pooled analysis
  • Oral and pharyngeal cancers

ASJC Scopus subject areas

  • Genetics(clinical)
  • Medicine(all)

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