Abstract
Here we review the prevalence of HIV-1 primary drug resistance in Latin America and Caribbean using meta-analysis as well as time-series modeling. We also discuss whether there could be a drawback to HIV/AIDS programs due to drug resistance in Latin America and Caribbean in the next years. We observed that, although some studies report low or moderate primary drug resistance prevalence in Caribbean countries, this evidence needs to be updated. In other countries, such as Brazil and Argentina, the prevalence of drug resistance appears to be rising. Mutations conferring resistance against reverse transcriptase inhibitors were the most frequent in the analyzed populations (70% of all mutational events). HIV-1 subtype B was the most prevalent in Latin America and the Caribbean, although subtype C and B/F recombinants have significant contributions in Argentina and Brazil. Thus, we suggest that primary drug resistance in Latin America and the Caribbean could have been underestimated. Clinical monitoring should be improved to offer better therapy, reducing the risk for HIV-1 resistance emergence and spread, principally in vulnerable populations, such as men who have sex with men transmission group, sex workers and intravenous drug users.
| Original language | English |
|---|---|
| Pages (from-to) | 125-142 |
| Number of pages | 18 |
| Journal | Current HIV Research |
| Volume | 13 |
| Issue number | 2 |
| Publication status | Published - 2015 |
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Keywords
- Drug resistance mutation
- HAART
- Meta-analysis
- Primary drug resistance
- Systematic review
- Time series
ASJC Scopus subject areas
- Infectious Diseases
- Virology
- Medicine(all)
Cite this
Meta-analysis and time series modeling allow a systematic review of primary HIV-1 drug-resistant prevalence in Latin America and Caribbean. / Campos Coelho, Antonio Victor; De Moura, Ronald Rodrigues; Da Silva, Ronaldo Celerino; Kamada, Anselmo Jiro; Guimarães, Rafael Lima; Brandão, Lucas André Cavalcanti; Coelho, Hemílio Fernandes Campos; Crovella, Sergio.
In: Current HIV Research, Vol. 13, No. 2, 2015, p. 125-142.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Meta-analysis and time series modeling allow a systematic review of primary HIV-1 drug-resistant prevalence in Latin America and Caribbean
AU - Campos Coelho, Antonio Victor
AU - De Moura, Ronald Rodrigues
AU - Da Silva, Ronaldo Celerino
AU - Kamada, Anselmo Jiro
AU - Guimarães, Rafael Lima
AU - Brandão, Lucas André Cavalcanti
AU - Coelho, Hemílio Fernandes Campos
AU - Crovella, Sergio
PY - 2015
Y1 - 2015
N2 - Here we review the prevalence of HIV-1 primary drug resistance in Latin America and Caribbean using meta-analysis as well as time-series modeling. We also discuss whether there could be a drawback to HIV/AIDS programs due to drug resistance in Latin America and Caribbean in the next years. We observed that, although some studies report low or moderate primary drug resistance prevalence in Caribbean countries, this evidence needs to be updated. In other countries, such as Brazil and Argentina, the prevalence of drug resistance appears to be rising. Mutations conferring resistance against reverse transcriptase inhibitors were the most frequent in the analyzed populations (70% of all mutational events). HIV-1 subtype B was the most prevalent in Latin America and the Caribbean, although subtype C and B/F recombinants have significant contributions in Argentina and Brazil. Thus, we suggest that primary drug resistance in Latin America and the Caribbean could have been underestimated. Clinical monitoring should be improved to offer better therapy, reducing the risk for HIV-1 resistance emergence and spread, principally in vulnerable populations, such as men who have sex with men transmission group, sex workers and intravenous drug users.
AB - Here we review the prevalence of HIV-1 primary drug resistance in Latin America and Caribbean using meta-analysis as well as time-series modeling. We also discuss whether there could be a drawback to HIV/AIDS programs due to drug resistance in Latin America and Caribbean in the next years. We observed that, although some studies report low or moderate primary drug resistance prevalence in Caribbean countries, this evidence needs to be updated. In other countries, such as Brazil and Argentina, the prevalence of drug resistance appears to be rising. Mutations conferring resistance against reverse transcriptase inhibitors were the most frequent in the analyzed populations (70% of all mutational events). HIV-1 subtype B was the most prevalent in Latin America and the Caribbean, although subtype C and B/F recombinants have significant contributions in Argentina and Brazil. Thus, we suggest that primary drug resistance in Latin America and the Caribbean could have been underestimated. Clinical monitoring should be improved to offer better therapy, reducing the risk for HIV-1 resistance emergence and spread, principally in vulnerable populations, such as men who have sex with men transmission group, sex workers and intravenous drug users.
KW - Drug resistance mutation
KW - HAART
KW - Meta-analysis
KW - Primary drug resistance
KW - Systematic review
KW - Time series
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UR - http://www.scopus.com/inward/citedby.url?scp=84930983012&partnerID=8YFLogxK
M3 - Article
C2 - 25777517
AN - SCOPUS:84930983012
VL - 13
SP - 125
EP - 142
JO - Current HIV Research
JF - Current HIV Research
SN - 1570-162X
IS - 2
ER -