Meta-analysis: Efficacy of small bowel preparation for small bowel video capsule endoscopy

Jonathan Belsey, Cristiano Crosta, Owen Epstein, Wolfgang Fischbach, Peter Layer, Fabrizio Parente, Marc Halphen

Research output: Contribution to journalArticlepeer-review


Objective: It is unclear whether small bowel visibility in video capsule endoscopy (VCE) is enhanced by the use of bowel preparation in addition to pre-procedural fasting. The objective of this study was to clarify this issue by means of a systematic review of the literature and meta-analysis. Methods: Randomised controlled trials comparing the use of laxative bowel preparation with fasting alone were identified using a literature search. Categorical measures of treatment efficacy were extracted from qualifying studies and pooled using random-effects meta-analyses. Primary analysis compared any bowel preparation with fasting alone; subsidiary analyses assessed diagnostic yield and results for each regimen. Results: Eight studies were identified, using either polyethylene glycol (PEG) or sodium phosphate (NaP) based regimens. No qualifying studies were identified using other laxatives. Study quality was sufficiently high to warrant meta-analysis. Use of any form of bowel preparation yielded significantly better visibility than fasting alone (OR=2.31; 95% CI=1.46-3.63; p

Original languageEnglish
Pages (from-to)1883-1890
Number of pages8
JournalCurrent Medical Research and Opinion
Issue number12
Publication statusPublished - Dec 2012


  • Bowel preparation
  • Capsule endoscopy
  • Meta analysis
  • Systematic review

ASJC Scopus subject areas

  • Medicine(all)


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