Meta-analysis of cancer incidence in children born after assisted reproductive technologies

S. Raimondi, P. Pedotti, E. Taioli

Research output: Contribution to journalArticlepeer-review

Abstract

A meta-analysis was performed on 11 cohort studies of Assisted Reproductive Technologies (ART) and subsequent childhood cancer, published up to February 2005, which reported comparable, nonoverlapping data, and then restricted to eight studies which presented a similar research design. The overall Standardised Incidence Ratio was 1.33 (95% CI 0.62-2.85), and 0.77 (95% CI 0.41-1.42) when the analysis was restricted to eight studies. No evidence of publication bias was observed for the overall analysis. The data are consistent with a lack of increase in risk of childhood cancer, though the amount of data on ART and cancer is still limited; larger multicentric studies as well as a pooled analysis on the available data are warranted.

Original languageEnglish
Pages (from-to)1053-1056
Number of pages4
JournalBritish Journal of Cancer
Volume93
Issue number9
DOIs
Publication statusPublished - Oct 31 2005

Keywords

  • Childhood chronic diseases
  • Cohort study
  • in vitro fertilisation

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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