TY - JOUR
T1 - Meta-analysis of diagnostic performance of serological tests for SARS-CoV-2 antibodies up to 25 April 2020 and public health implications
AU - Caini, Saverio
AU - Bellerba, Federica
AU - Corso, Federica
AU - Díaz-Basabe, Angélica
AU - Natoli, Gioacchino
AU - Paget, John
AU - Facciotti, Federica
AU - De Angelis, Simone Pietro
AU - Raimondi, Sara
AU - Palli, Domenico
AU - Mazzarella, Luca
AU - Pelicci, Pier Giuseppe
AU - Vineis, Paolo
AU - Gandini, Sara
N1 - Publisher Copyright:
© 2020 European Centre for Disease Prevention and Control (ECDC). All rights reserved.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/6/11
Y1 - 2020/6/11
N2 - We reviewed the diagnostic accuracy of SARS-CoV-2 serological tests. Random-effects models yielded a summary sensitivity of 82% for IgM, and 85% for IgG and total antibodies. For specificity, the pooled estimate were 98% for IgM and 99% for IgG and total antibodies. In populations with ≤ 5% of seroconverted individuals, unless the assays have perfect (i.e. 100%) specificity, the positive predictive value would be ≤ 88%. Serological tests should be used for prevalence surveys only in hard-hit areas.
AB - We reviewed the diagnostic accuracy of SARS-CoV-2 serological tests. Random-effects models yielded a summary sensitivity of 82% for IgM, and 85% for IgG and total antibodies. For specificity, the pooled estimate were 98% for IgM and 99% for IgG and total antibodies. In populations with ≤ 5% of seroconverted individuals, unless the assays have perfect (i.e. 100%) specificity, the positive predictive value would be ≤ 88%. Serological tests should be used for prevalence surveys only in hard-hit areas.
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U2 - 10.2807/1560-7917.ES.2020.25.23.2000980
DO - 10.2807/1560-7917.ES.2020.25.23.2000980
M3 - Article
C2 - 32553061
AN - SCOPUS:85086691716
VL - 25
JO - Eurosurveillance
JF - Eurosurveillance
SN - 1560-7917
IS - 23
M1 - 2000980
ER -