Meta-analysis of diagnostic performance of serological tests for SARS-CoV-2 antibodies up to 25 April 2020 and public health implications

Saverio Caini; Federica Bellerba; Federica Corso; Angélica Díaz-Basabe; Gioacchino Natoli; John Paget; Federica Facciotti; Simone Pietro De Angelis; Sara Raimondi; Domenico Palli; Luca Mazzarella; Pier Giuseppe Pelicci; Paolo Vineis; Sara Gandini

doi:10.2807/1560-7917.ES.2020.25.23.2000980

Meta-analysis of diagnostic performance of serological tests for SARS-CoV-2 antibodies up to 25 April 2020 and public health implications

Saverio Caini, Federica Bellerba, Federica Corso, Angélica Díaz-Basabe, Gioacchino Natoli, John Paget, Federica Facciotti, Simone Pietro De Angelis, Sara Raimondi, Domenico Palli, Luca Mazzarella, Pier Giuseppe Pelicci, Paolo Vineis, Sara Gandini

Istituto Europeo di Oncologia

Research output: Contribution to journal › Article › peer-review

Abstract

We reviewed the diagnostic accuracy of SARS-CoV-2 serological tests. Random-effects models yielded a summary sensitivity of 82% for IgM, and 85% for IgG and total antibodies. For specificity, the pooled estimate were 98% for IgM and 99% for IgG and total antibodies. In populations with ≤ 5% of seroconverted individuals, unless the assays have perfect (i.e. 100%) specificity, the positive predictive value would be ≤ 88%. Serological tests should be used for prevalence surveys only in hard-hit areas.

Original language	English
Article number	2000980
Journal	Eurosurveillance
Volume	25
Issue number	23
DOIs	https://doi.org/10.2807/1560-7917.ES.2020.25.23.2000980
Publication status	Published - Jun 11 2020

ASJC Scopus subject areas

Epidemiology
Public Health, Environmental and Occupational Health
Virology

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Caini, S., Bellerba, F., Corso, F., Díaz-Basabe, A., Natoli, G., Paget, J., Facciotti, F., De Angelis, S. P., Raimondi, S., Palli, D., Mazzarella, L., Pelicci, P. G., Vineis, P., & Gandini, S. (2020). Meta-analysis of diagnostic performance of serological tests for SARS-CoV-2 antibodies up to 25 April 2020 and public health implications. Eurosurveillance, 25(23), [2000980]. https://doi.org/10.2807/1560-7917.ES.2020.25.23.2000980

Caini, S, Bellerba, F , Corso, F , Díaz-Basabe, A , Natoli, G, Paget, J, Facciotti, F, De Angelis, SP, Raimondi, S, Palli, D, Mazzarella, L , Pelicci, PG, Vineis, P & Gandini, S 2020, 'Meta-analysis of diagnostic performance of serological tests for SARS-CoV-2 antibodies up to 25 April 2020 and public health implications', Eurosurveillance, vol. 25, no. 23, 2000980. https://doi.org/10.2807/1560-7917.ES.2020.25.23.2000980

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AU - Díaz-Basabe, Angélica

AU - Natoli, Gioacchino

AU - Paget, John

AU - Facciotti, Federica

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AU - Raimondi, Sara

AU - Palli, Domenico

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Meta-analysis of diagnostic performance of serological tests for SARS-CoV-2 antibodies up to 25 April 2020 and public health implications

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