Meta-analysis of risk factors for cutaneous melanoma: I. Common and atypical naevi

Sara Gandini, Francesco Sera, Maria Sofia Cattaruzza, Paolo Pasquini, Damiano Abeni, Peter Boyle, Carmelo Francesco Melchi

Research output: Contribution to journalArticlepeer-review

Abstract

A systematic meta-analysis of observational studies of melanoma and one of the most important risk factors, the number of naevi, was conducted in order to clarify aspects of the aetiology of this disease. Following a systematic literature search, relative risks (RRs) were extracted from 46 studies published before September 2002. Dose-response random effects models were used to obtain pooled estimates. Sub-group analysis and meta-regression were carried out to explore sources of between-study variation and bias. Sensitivity analyses investigated the reliability of the results and any publication bias. Number of common naevi was confirmed an important risk factor with a substantially increased risk associated with the presence of 101-120 naevi compared with

Original languageEnglish
Pages (from-to)28-44
Number of pages17
JournalEuropean Journal of Cancer
Volume41
Issue number1
DOIs
Publication statusPublished - Jan 2005

Keywords

  • Epidemiology
  • Melanoma
  • Meta-analysis
  • Naevus
  • Review literature

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

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