Meta-analysis of the impact of mitral regurgitation on outcomes after transcatheter aortic valve implantation

Tarun Chakravarty, Eric Van Belle, Hasan Jilaihawi, Amit Noheria, Luca Testa, Francesco Bedogni, Andreas Rück, Marco Barbanti, Stefan Toggweiler, Martyn Thomas, Muhammed Z eeshan Khawaja, Andrea Hutter, Yigal Abramowitz, Robert J. Siegel, Wen Cheng, John Webb, Martin B. Leon, Raj R. Makkar

Research output: Contribution to journalArticle

Abstract

Significant mitral regurgitation (MR) constitutes an important co-existing valvular heart disease burden in the setting of aortic valve stenosis. There are conflicting reports on the impact of significant MR on outcomes after transcatheter aortic valve implantation (TAVI). We evaluated the impact of MR on outcomes after TAVI by performing a meta-analysis of 8 studies involving 8,927 patients reporting TAVI outcomes based on the presence or absence of moderate-severe MR. Risk ratios (RRs) were calculated using the inverse variance random-effects model. None-mild MR was present in 77.8% and moderate-severe MR in 22.2% of the patients. The presence of moderate-severe MR at baseline was associated with increased mortality at 30 days (RR 1.35, 95% confidence interval [CI] 1.14 to 1.59, p = 0.003) and 1 year (RR 1.24, 95% CI 1.13 to 1.37, p

Original languageEnglish
Pages (from-to)942-949
Number of pages8
JournalThe American Journal of Cardiology
Volume115
Issue number7
DOIs
Publication statusPublished - Apr 1 2015

ASJC Scopus subject areas

  • Medicine(all)

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