Meta-analysis study on the role of bone-derived neurotrophic factor Val66Met polymorphism in Parkinson's disease

Stefania Mariani; Mariacarla Ventriglia; Illaria Simonelli; Serena Bucossi; Mariacristina Siotto; Rosanna R. Squitti

doi:10.1089/rej.2014.1612

Meta-analysis study on the role of bone-derived neurotrophic factor Val66Met polymorphism in Parkinson's disease

Stefania Mariani, Mariacarla Ventriglia, Illaria Simonelli, Serena Bucossi, Mariacristina Siotto, Rosanna R. Squitti

Research output: Contribution to journal › Article

Abstract

To evaluate a possible involvement of the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism in susceptibility to Parkinson's disease (PD), we performed a meta-analysis of all studies on the topic published from 2002 to 2014. This article reviews and compares the data from two previous meta-analyses, including two studies not previously considered. We selected studies referring to a genetic comparison between PD patients and healthy controls, so 15 studies involving 3754 cases and 4026 controls were included in our meta-analysis. We found no association between the Val66Met polymorphism and the risk of developing PD in our overall analysis. The ethnicity-specific meta-analysis produced no significant association either. Our data do not support a major role for the BDNF Val66Met polymorphism in the pathogenesis of PD.

Original language	English
Pages (from-to)	40-47
Number of pages	8
Journal	Rejuvenation Research
Volume	18
Issue number	1
DOIs	https://doi.org/10.1089/rej.2014.1612
Publication status	Published - Feb 1 2015

ASJC Scopus subject areas

Ageing
Geriatrics and Gerontology
Medicine(all)

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Mariani, S., Ventriglia, M., Simonelli, I., Bucossi, S., Siotto, M., & Squitti, R. R. (2015). Meta-analysis study on the role of bone-derived neurotrophic factor Val66Met polymorphism in Parkinson's disease. Rejuvenation Research, 18(1), 40-47. https://doi.org/10.1089/rej.2014.1612

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