Meta-analysis study on the role of bone-derived neurotrophic factor Val66Met polymorphism in Parkinson's disease

Stefania Mariani, Mariacarla Ventriglia, Illaria Simonelli, Serena Bucossi, Mariacristina Siotto, Rosanna R. Squitti

Research output: Contribution to journalArticle

Abstract

To evaluate a possible involvement of the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism in susceptibility to Parkinson's disease (PD), we performed a meta-analysis of all studies on the topic published from 2002 to 2014. This article reviews and compares the data from two previous meta-analyses, including two studies not previously considered. We selected studies referring to a genetic comparison between PD patients and healthy controls, so 15 studies involving 3754 cases and 4026 controls were included in our meta-analysis. We found no association between the Val66Met polymorphism and the risk of developing PD in our overall analysis. The ethnicity-specific meta-analysis produced no significant association either. Our data do not support a major role for the BDNF Val66Met polymorphism in the pathogenesis of PD.

Original languageEnglish
Pages (from-to)40-47
Number of pages8
JournalRejuvenation Research
Volume18
Issue number1
DOIs
Publication statusPublished - Feb 1 2015

ASJC Scopus subject areas

  • Ageing
  • Geriatrics and Gerontology
  • Medicine(all)

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