TY - JOUR
T1 - Meta-analysis study on the role of bone-derived neurotrophic factor Val66Met polymorphism in Parkinson's disease
AU - Mariani, Stefania
AU - Ventriglia, Mariacarla
AU - Simonelli, Illaria
AU - Bucossi, Serena
AU - Siotto, Mariacristina
AU - Squitti, Rosanna R.
PY - 2015/2/1
Y1 - 2015/2/1
N2 - To evaluate a possible involvement of the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism in susceptibility to Parkinson's disease (PD), we performed a meta-analysis of all studies on the topic published from 2002 to 2014. This article reviews and compares the data from two previous meta-analyses, including two studies not previously considered. We selected studies referring to a genetic comparison between PD patients and healthy controls, so 15 studies involving 3754 cases and 4026 controls were included in our meta-analysis. We found no association between the Val66Met polymorphism and the risk of developing PD in our overall analysis. The ethnicity-specific meta-analysis produced no significant association either. Our data do not support a major role for the BDNF Val66Met polymorphism in the pathogenesis of PD.
AB - To evaluate a possible involvement of the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism in susceptibility to Parkinson's disease (PD), we performed a meta-analysis of all studies on the topic published from 2002 to 2014. This article reviews and compares the data from two previous meta-analyses, including two studies not previously considered. We selected studies referring to a genetic comparison between PD patients and healthy controls, so 15 studies involving 3754 cases and 4026 controls were included in our meta-analysis. We found no association between the Val66Met polymorphism and the risk of developing PD in our overall analysis. The ethnicity-specific meta-analysis produced no significant association either. Our data do not support a major role for the BDNF Val66Met polymorphism in the pathogenesis of PD.
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U2 - 10.1089/rej.2014.1612
DO - 10.1089/rej.2014.1612
M3 - Article
C2 - 25431370
AN - SCOPUS:84923334570
VL - 18
SP - 40
EP - 47
JO - Rejuvenation Research
JF - Rejuvenation Research
SN - 1549-1684
IS - 1
ER -