Meta-analysis: The outcome of anti-viral therapy in HCV genotype 2 and genotype 3 infected patients with chronic hepatitis

A. Andriulli, A. Mangia, A. Iacobellis, A. Ippolito, G. Leandro, S. Zeuzem

Research output: Contribution to journalArticle

Abstract

Background: Anti-viral therapy seems more successful in HCV genotype 2 than genotype 3-infected patients. Aim: To report sustained virological response (SVR) rates for HCV-2 and HCV-3 infection. Methods: Meta-analyses were carried out on SVR data on 2275 patients treated for 24 weeks in eight individual trials and on 968 patients with rapid virological response (RVR) treated for 12-16 weeks or 24 weeks in four studies. Results: After 24 weeks of therapy, SVR rates were 74% and 68%, respectively, for HCV-2 and HCV-3 genotype patients. Among high viraemics, SVR rate in HCV-2 infection (75%) differed from the 58% value in HCV-3 infection. Among low viraemic patients, respective rates were 79% and 75%. In RVR patients treated for 12-16 or 24 weeks, SVR rates in HCV-2 infection were 83% and 84%, respectively, and in HCV-3 infection 84% and 86%. In patients without RVR treated for 24 weeks, SVR was higher in HCV-2, with a 17.8% weighted difference. Conclusions: Twenty-four weeks of therapy should remain standard duration for HCV-2 and low viraemic HCV-3 patients. In RVR patients, HCV-3 patients respond to short-treatment as well as HCV-2 patients, irrespective of basal viraemia. Patients without RVR may need longer treatment than the recommended 24 weeks.

Original languageEnglish
Pages (from-to)397-404
Number of pages8
JournalAlimentary Pharmacology and Therapeutics
Volume28
Issue number4
DOIs
Publication statusPublished - Aug 2008

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ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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