Meta- and pooled analysis of GSTT1 and lung cancer: A HuGE-GSEC review

S. Raimondi, V. Paracchini, H. Autrup, J. M. Barros-Dios, S. Benhamou, P. Boffetta, M. L. Cote, I. A. Dialyna, V. Dolzan, R. Filiberti, S. Garte, A. Hirvonen, K. Husgafvel-Pursiainen, E. N. Imyanitov, I. Kalina, D. Kang, C. Kiyohara, T. Kohno, P. Kremers, Q. LanS. London, A. C. Povey, A. Rannug, E. Reszka, A. Risch, M. Romkes, J. Schneider, A. Seow, P. G. Shields, R. C. Sobti, M. Sørensen, M. Spinola, M. R. Spitz, R. C. Strange, I. Stücker, H. Sugimura, J. To-Figueras, S. Tokudome, P. Yang, J. M. Yuan, M. Warholm, E. Taioli

Research output: Contribution to journalArticle

Abstract

Lung cancer is the most common malignancy in the Western world, and the main risk factor is tobacco smoking. Polymorphisms in metabolic genes may modulate the risk associated with environmental factors. The glutathione S-transferase theta 1 gene (GSTT1) is a particularly attractive candidate for lung cancer susceptibility because of its involvement in the metabolism of polycyclic aromatic hydrocarbons found in tobacco smoke and of other chemicals, pesticides, and industrial solvents. The frequency of the GSTT1 null genotype is lower among Caucasians (10-20%) than among Asians (50-60%). The authors present a meta- and a pooled analysis of case-control, genotype-based studies that examined the association between GSTT1 and lung cancer (34 studies, 7,629 cases and 10,087 controls for the meta-analysis; 34 studies, 7,044 cases and 10,000 controls for the pooled analysis). No association was observed between GSTT1 deletion and lung cancer for Caucasians (odds ratio (OR) = 0.99, 95% confidence interval (CI): 0.87, 1.12); for Asians, a positive association was found (OR = 1.28, 95% CI: 1.10, 1.49). In the pooled analysis, the odds ratios were not significant for either Asians (OR = 0.97, 95% CI: 0.83, 1.13) or Caucasians (OR = 1.09, 95% CI: 0.99, 1.21). No significant interaction was observed between GSTT1 and smoking on lung cancer, whereas GSTT1 appeared to modulate occupational-related lung cancer.

Original languageEnglish
Pages (from-to)1027-1042
Number of pages16
JournalAmerican Journal of Epidemiology
Volume164
Issue number11
DOIs
Publication statusPublished - Dec 2006

Fingerprint

Meta-Analysis
Lung Neoplasms
Odds Ratio
Confidence Intervals
Genes
Smoking
Genotype
Western World
Polycyclic Aromatic Hydrocarbons
Gene Deletion
Pesticides
Smoke
Tobacco
glutathione S-transferase T1
Neoplasms

Keywords

  • Disease susceptibility
  • Epidemiology
  • Genes
  • Genetic predisposition to disease
  • GSTT1
  • Lung neoplasms
  • Meta-analysis

ASJC Scopus subject areas

  • Epidemiology

Cite this

Raimondi, S., Paracchini, V., Autrup, H., Barros-Dios, J. M., Benhamou, S., Boffetta, P., ... Taioli, E. (2006). Meta- and pooled analysis of GSTT1 and lung cancer: A HuGE-GSEC review. American Journal of Epidemiology, 164(11), 1027-1042. https://doi.org/10.1093/aje/kwj321

Meta- and pooled analysis of GSTT1 and lung cancer : A HuGE-GSEC review. / Raimondi, S.; Paracchini, V.; Autrup, H.; Barros-Dios, J. M.; Benhamou, S.; Boffetta, P.; Cote, M. L.; Dialyna, I. A.; Dolzan, V.; Filiberti, R.; Garte, S.; Hirvonen, A.; Husgafvel-Pursiainen, K.; Imyanitov, E. N.; Kalina, I.; Kang, D.; Kiyohara, C.; Kohno, T.; Kremers, P.; Lan, Q.; London, S.; Povey, A. C.; Rannug, A.; Reszka, E.; Risch, A.; Romkes, M.; Schneider, J.; Seow, A.; Shields, P. G.; Sobti, R. C.; Sørensen, M.; Spinola, M.; Spitz, M. R.; Strange, R. C.; Stücker, I.; Sugimura, H.; To-Figueras, J.; Tokudome, S.; Yang, P.; Yuan, J. M.; Warholm, M.; Taioli, E.

In: American Journal of Epidemiology, Vol. 164, No. 11, 12.2006, p. 1027-1042.

Research output: Contribution to journalArticle

Raimondi, S, Paracchini, V, Autrup, H, Barros-Dios, JM, Benhamou, S, Boffetta, P, Cote, ML, Dialyna, IA, Dolzan, V, Filiberti, R, Garte, S, Hirvonen, A, Husgafvel-Pursiainen, K, Imyanitov, EN, Kalina, I, Kang, D, Kiyohara, C, Kohno, T, Kremers, P, Lan, Q, London, S, Povey, AC, Rannug, A, Reszka, E, Risch, A, Romkes, M, Schneider, J, Seow, A, Shields, PG, Sobti, RC, Sørensen, M, Spinola, M, Spitz, MR, Strange, RC, Stücker, I, Sugimura, H, To-Figueras, J, Tokudome, S, Yang, P, Yuan, JM, Warholm, M & Taioli, E 2006, 'Meta- and pooled analysis of GSTT1 and lung cancer: A HuGE-GSEC review', American Journal of Epidemiology, vol. 164, no. 11, pp. 1027-1042. https://doi.org/10.1093/aje/kwj321
Raimondi S, Paracchini V, Autrup H, Barros-Dios JM, Benhamou S, Boffetta P et al. Meta- and pooled analysis of GSTT1 and lung cancer: A HuGE-GSEC review. American Journal of Epidemiology. 2006 Dec;164(11):1027-1042. https://doi.org/10.1093/aje/kwj321
Raimondi, S. ; Paracchini, V. ; Autrup, H. ; Barros-Dios, J. M. ; Benhamou, S. ; Boffetta, P. ; Cote, M. L. ; Dialyna, I. A. ; Dolzan, V. ; Filiberti, R. ; Garte, S. ; Hirvonen, A. ; Husgafvel-Pursiainen, K. ; Imyanitov, E. N. ; Kalina, I. ; Kang, D. ; Kiyohara, C. ; Kohno, T. ; Kremers, P. ; Lan, Q. ; London, S. ; Povey, A. C. ; Rannug, A. ; Reszka, E. ; Risch, A. ; Romkes, M. ; Schneider, J. ; Seow, A. ; Shields, P. G. ; Sobti, R. C. ; Sørensen, M. ; Spinola, M. ; Spitz, M. R. ; Strange, R. C. ; Stücker, I. ; Sugimura, H. ; To-Figueras, J. ; Tokudome, S. ; Yang, P. ; Yuan, J. M. ; Warholm, M. ; Taioli, E. / Meta- and pooled analysis of GSTT1 and lung cancer : A HuGE-GSEC review. In: American Journal of Epidemiology. 2006 ; Vol. 164, No. 11. pp. 1027-1042.
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AU - Raimondi, S.

AU - Paracchini, V.

AU - Autrup, H.

AU - Barros-Dios, J. M.

AU - Benhamou, S.

AU - Boffetta, P.

AU - Cote, M. L.

AU - Dialyna, I. A.

AU - Dolzan, V.

AU - Filiberti, R.

AU - Garte, S.

AU - Hirvonen, A.

AU - Husgafvel-Pursiainen, K.

AU - Imyanitov, E. N.

AU - Kalina, I.

AU - Kang, D.

AU - Kiyohara, C.

AU - Kohno, T.

AU - Kremers, P.

AU - Lan, Q.

AU - London, S.

AU - Povey, A. C.

AU - Rannug, A.

AU - Reszka, E.

AU - Risch, A.

AU - Romkes, M.

AU - Schneider, J.

AU - Seow, A.

AU - Shields, P. G.

AU - Sobti, R. C.

AU - Sørensen, M.

AU - Spinola, M.

AU - Spitz, M. R.

AU - Strange, R. C.

AU - Stücker, I.

AU - Sugimura, H.

AU - To-Figueras, J.

AU - Tokudome, S.

AU - Yang, P.

AU - Yuan, J. M.

AU - Warholm, M.

AU - Taioli, E.

PY - 2006/12

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N2 - Lung cancer is the most common malignancy in the Western world, and the main risk factor is tobacco smoking. Polymorphisms in metabolic genes may modulate the risk associated with environmental factors. The glutathione S-transferase theta 1 gene (GSTT1) is a particularly attractive candidate for lung cancer susceptibility because of its involvement in the metabolism of polycyclic aromatic hydrocarbons found in tobacco smoke and of other chemicals, pesticides, and industrial solvents. The frequency of the GSTT1 null genotype is lower among Caucasians (10-20%) than among Asians (50-60%). The authors present a meta- and a pooled analysis of case-control, genotype-based studies that examined the association between GSTT1 and lung cancer (34 studies, 7,629 cases and 10,087 controls for the meta-analysis; 34 studies, 7,044 cases and 10,000 controls for the pooled analysis). No association was observed between GSTT1 deletion and lung cancer for Caucasians (odds ratio (OR) = 0.99, 95% confidence interval (CI): 0.87, 1.12); for Asians, a positive association was found (OR = 1.28, 95% CI: 1.10, 1.49). In the pooled analysis, the odds ratios were not significant for either Asians (OR = 0.97, 95% CI: 0.83, 1.13) or Caucasians (OR = 1.09, 95% CI: 0.99, 1.21). No significant interaction was observed between GSTT1 and smoking on lung cancer, whereas GSTT1 appeared to modulate occupational-related lung cancer.

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KW - Disease susceptibility

KW - Epidemiology

KW - Genes

KW - Genetic predisposition to disease

KW - GSTT1

KW - Lung neoplasms

KW - Meta-analysis

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