Meta-review of metanalytic studies with repetitive transcranial magnetic stimulation (rTMS) for the treatment of Major Depression

Bernardo Dell'Osso, Giulia Camuri, Filippo Castellano, Vittoria Vecchi, Matteo Benedetti, Sara Bortolussi, A. Carlo Altamura

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Background: Major Depression (MD) and treatment-resistant depression (TRD) are worldwide leading causes of disability and therapeutic strategies for these impairing and prevalent conditions include pharmacological augmentation strategies and brain stimulation techniques. In this perspective, repetitive transcranial magnetic stimulation (rTMS) is a non-invasive brain stimulation technique with a favorable profile of tolerability which, despite being recently approved by the Food and Drug Administration (FDA) for the treatment of patients with medication-refractory unipolar depression, still raises some doubts about most effective parameters of stimulation. Methods: A literature search was performed using PubMed for the years 2001 through February 2011 in order to review meta-analytic studies assessing efficacy and safety issues for rTMS in depressive disorders. Fifteen meta-analyses were identified and critically discussed in order to provide an updated and comprehensive overview of the topic with specific emphasis on potentially optimal parameters of stimulation. Results: First meta-analyses on the efficacy of rTMS for the treatment of MD and TRD have shown mixed results. On the other hand, more recent meta-analytic studies seem to support the antidepressant efficacy of the technique to a greater extent, also in light of longer periods of stimulation (e.g. > 2 weeks). Conclusion: rTMS seems to be an effective and safe brain stimulation technique for the treatment of medication refractory depression. Nevertheless, further studies are needed to better define specific stimulation-related issues, such as duration of treatment as well as durability of effects and predictors of response.

Original languageEnglish
Pages (from-to)167-177
Number of pages11
JournalClinical Practice and Epidemiology in Mental Health
Volume7
DOIs
Publication statusPublished - 2011

Fingerprint

Transcranial Magnetic Stimulation
Treatment-Resistant Depressive Disorder
Depression
Depressive Disorder
Meta-Analysis
Brain
Therapeutics
United States Food and Drug Administration
PubMed
Antidepressive Agents
Pharmacology
Safety

Keywords

  • Major depression (MD)
  • Meta-analyses
  • Transcranial magnetic stimulation (rTMS)
  • Treatment-resistant depression (TRD)

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Epidemiology

Cite this

Meta-review of metanalytic studies with repetitive transcranial magnetic stimulation (rTMS) for the treatment of Major Depression. / Dell'Osso, Bernardo; Camuri, Giulia; Castellano, Filippo; Vecchi, Vittoria; Benedetti, Matteo; Bortolussi, Sara; Altamura, A. Carlo.

In: Clinical Practice and Epidemiology in Mental Health, Vol. 7, 2011, p. 167-177.

Research output: Contribution to journalArticle

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