Metabolic adaptation during a sequence of no-flow and low-flow ischemia: A possible trigger for hibernation

R. Ferrari, A. Cargnoni, P. Bernocchi, E. Pasini, S. Curello, C. Ceconi, T. J C Ruigrok

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Myocardial hibernation is an adaptive phenomenon occurring in patients with a history of acute ischemia followed by prolonged hypoperfusion. Methods and Results: We investigated, in isolated rabbit heart, whether a brief episode of global ischemia followed by hypoperfusion maintains viability. Four groups were studied: group 1, 300 minutes of aerobia; group 2, 240 minutes of total ischemia and 60 minutes of reperfusion; group 3, 10 minutes of total ischemia, 230 minutes of hypoperfusion (90% coronary flow reduction), and 60 minutes of reperfusion; and group 4, 240 minutes of hypoperfusion followed by reperfusion. In group 3, viability was maintained. Ten minutes of ischemia caused quiescence, a fall in interstitial pH (from 7.2±0.01 to 6.1±0.8), creatine phosphate (CP), and ATP (from 54.5±5.0 and 25.0±1.9 to 5.0±1.1 and 15.3±2.5 μmol/g dry wt, P

Original languageEnglish
Pages (from-to)2587-2596
Number of pages10
JournalCirculation
Volume94
Issue number10
Publication statusPublished - 1996

Keywords

  • ischemia
  • metabolism
  • myocardial hibernation
  • preconditioning

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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