Metabolic agents in the management of diabetic coronary patients: A new era

Research output: Contribution to journalArticle


The modulation of cardiac metabolism with Trimetazidine is very important for the control of myocardial ischemia and for the preservation of left ventricular function. The optimization of cardiac metabolism should also include improvement of cardiac insulin resistance with insulin sensitizer agents and the optimization of Kreb's Cycle with essential amino acids. Regarding new drugs that may act inhibiting free fatty acid oxidation we have to underline that to date it is not clear whether Ranolazine has an effect on cardiac metabolism. We agree instead that metabolic agents like Dichloroacetate, Perhexiline and Etomoxir have an antiischemic effect, while their administration requires adjustment of dose and careful monitoring of side effects.

Original languageEnglish
Pages (from-to)124-125
Number of pages2
JournalInternational Journal of Cardiology
Issue number1
Publication statusPublished - Jun 23 2008


  • Coronary artery disease
  • Diabetes
  • Metabolic agents

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Metabolic agents in the management of diabetic coronary patients: A new era'. Together they form a unique fingerprint.

  • Cite this