Metabolic agents in the management of diabetic coronary patients

A new era

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The modulation of cardiac metabolism with Trimetazidine is very important for the control of myocardial ischemia and for the preservation of left ventricular function. The optimization of cardiac metabolism should also include improvement of cardiac insulin resistance with insulin sensitizer agents and the optimization of Kreb's Cycle with essential amino acids. Regarding new drugs that may act inhibiting free fatty acid oxidation we have to underline that to date it is not clear whether Ranolazine has an effect on cardiac metabolism. We agree instead that metabolic agents like Dichloroacetate, Perhexiline and Etomoxir have an antiischemic effect, while their administration requires adjustment of dose and careful monitoring of side effects.

Original languageEnglish
Pages (from-to)124-125
Number of pages2
JournalInternational Journal of Cardiology
Volume127
Issue number1
DOIs
Publication statusPublished - Jun 23 2008

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Perhexiline
Trimetazidine
Essential Amino Acids
Left Ventricular Function
Nonesterified Fatty Acids
Myocardial Ischemia
Insulin Resistance
Insulin
Pharmaceutical Preparations
etomoxir
Ranolazine

Keywords

  • Coronary artery disease
  • Diabetes
  • Metabolic agents

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

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abstract = "The modulation of cardiac metabolism with Trimetazidine is very important for the control of myocardial ischemia and for the preservation of left ventricular function. The optimization of cardiac metabolism should also include improvement of cardiac insulin resistance with insulin sensitizer agents and the optimization of Kreb's Cycle with essential amino acids. Regarding new drugs that may act inhibiting free fatty acid oxidation we have to underline that to date it is not clear whether Ranolazine has an effect on cardiac metabolism. We agree instead that metabolic agents like Dichloroacetate, Perhexiline and Etomoxir have an antiischemic effect, while their administration requires adjustment of dose and careful monitoring of side effects.",
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AU - Marazzi, Giuseppe

AU - Volterrani, Maurizio

AU - Rosano, G. M C

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AB - The modulation of cardiac metabolism with Trimetazidine is very important for the control of myocardial ischemia and for the preservation of left ventricular function. The optimization of cardiac metabolism should also include improvement of cardiac insulin resistance with insulin sensitizer agents and the optimization of Kreb's Cycle with essential amino acids. Regarding new drugs that may act inhibiting free fatty acid oxidation we have to underline that to date it is not clear whether Ranolazine has an effect on cardiac metabolism. We agree instead that metabolic agents like Dichloroacetate, Perhexiline and Etomoxir have an antiischemic effect, while their administration requires adjustment of dose and careful monitoring of side effects.

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KW - Metabolic agents

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