Metabolic alteration transients during paroxysmal activity in an epileptic patient with fixation-off sensitivity: a case study

Federico Giove, Girolamo Garreffa, Stefano Peca, Marco Carní, Maria Antonietta Macrì, Carlo Di Bonaventura, Anna Elisabetta Vaudano, Anna Teresa Giallonardo, Massimiliano Prencipe, Luigi Bozzao, Patrizia Pantano, Claudio Colonnese, Bruno Maraviglia

Research output: Contribution to journalArticlepeer-review

Abstract

The purpose of this study was to investigate short-time metabolic variations related to continuous epileptic activity elicited by fixation-off sensitivity (FOS). Time-resolved magnetic resonance spectroscopy was performed on a patient on whom previous clinical findings clearly indicated presence of FOS. The epileptic focus was localized with a simultaneous electroencephalographic and functional magnetic resonance imaging study. The results showed a linear increase of the sum of glutamate and glutamine with time of paroxysmal activity in epileptic focus and much greater concentration of choline-containing compounds in focus than in the contralateral side.

Original languageEnglish
Pages (from-to)373-379
Number of pages7
JournalMagnetic Resonance Imaging
Volume24
Issue number4
DOIs
Publication statusPublished - May 2006

Keywords

  • Epilepsy
  • Fixation-off sensitivity
  • Functional magnetic resonance spectroscopy
  • Glutamate
  • Time resolved

ASJC Scopus subject areas

  • Biophysics
  • Clinical Biochemistry
  • Structural Biology
  • Radiology Nuclear Medicine and imaging
  • Condensed Matter Physics

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