Metabolic alterations in patients who develop traumatic brain injury (TBI)-induced hypopituitarism

F. Prodam, V. Gasco, M. Caputo, M. Zavattaro, L. Pagano, P. Marzullo, S. Belcastro, A. Busti, C. Perino, S. Grottoli, E. Ghigo, G. Aimaretti

Research output: Contribution to journalArticlepeer-review


Objective: Hypopituitarism is associated with metabolic alterations but in TBI-induced hypopituitarism data are scanty. The aim of our study was to evaluate the prevalence of naïve hypertension, dyslipidemia, and altered glucose metabolism in TBI-induced hypopituitarism patients. Design: Cross-sectional retrospective study in a tertiary care endocrinology center. 54 adult patients encountering a moderate or severe TBI were evaluated in the chronic phase (at least 12. months after injury) after-trauma. Presence of hypopituitarism, BMI, hypertension, fasting blood glucose and insulin levels, oral glucose tolerance test (if available) and a lipid profile were evaluated. Results: The 27.8% of patients showed various degrees of hypopituitarism. In particular, 9.3% had total, 7.4% multiple and 11.1% isolated hypopituitarism. GHD was present in 22.2% of patients. BMI was similar between the two groups. Hypopituitaric patients presented a higher prevalence of dyslipidemia (p.

Original languageEnglish
Pages (from-to)109-113
Number of pages5
JournalGrowth Hormone and IGF Research
Issue number4
Publication statusPublished - Aug 2013


  • BMI
  • GCS
  • Glucose metabolism
  • HDL-cholesterol
  • Hypopituitarism
  • Lipids
  • TBI
  • Traumatic brain injury

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism


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