Metabolic alterations in patients who develop traumatic brain injury (TBI)-induced hypopituitarism

F. Prodam, V. Gasco, M. Caputo, M. Zavattaro, L. Pagano, P. Marzullo, S. Belcastro, A. Busti, C. Perino, S. Grottoli, E. Ghigo, G. Aimaretti

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Objective: Hypopituitarism is associated with metabolic alterations but in TBI-induced hypopituitarism data are scanty. The aim of our study was to evaluate the prevalence of naïve hypertension, dyslipidemia, and altered glucose metabolism in TBI-induced hypopituitarism patients. Design: Cross-sectional retrospective study in a tertiary care endocrinology center. 54 adult patients encountering a moderate or severe TBI were evaluated in the chronic phase (at least 12. months after injury) after-trauma. Presence of hypopituitarism, BMI, hypertension, fasting blood glucose and insulin levels, oral glucose tolerance test (if available) and a lipid profile were evaluated. Results: The 27.8% of patients showed various degrees of hypopituitarism. In particular, 9.3% had total, 7.4% multiple and 11.1% isolated hypopituitarism. GHD was present in 22.2% of patients. BMI was similar between the two groups. Hypopituitaric patients presented a higher prevalence of dyslipidemia (p.

Original languageEnglish
Pages (from-to)109-113
Number of pages5
JournalGrowth Hormone and IGF Research
Volume23
Issue number4
DOIs
Publication statusPublished - Aug 2013

Fingerprint

Hypopituitarism
Dyslipidemias
Hypertension
Endocrinology
Wounds and Injuries
Glucose Tolerance Test
Tertiary Care Centers
Blood Glucose
Traumatic Brain Injury
Fasting
Retrospective Studies
Cross-Sectional Studies
Insulin
Lipids
Glucose

Keywords

  • BMI
  • GCS
  • Glucose metabolism
  • HDL-cholesterol
  • HOMA-IR
  • Hypopituitarism
  • Lipids
  • TBI
  • Traumatic brain injury

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Metabolic alterations in patients who develop traumatic brain injury (TBI)-induced hypopituitarism. / Prodam, F.; Gasco, V.; Caputo, M.; Zavattaro, M.; Pagano, L.; Marzullo, P.; Belcastro, S.; Busti, A.; Perino, C.; Grottoli, S.; Ghigo, E.; Aimaretti, G.

In: Growth Hormone and IGF Research, Vol. 23, No. 4, 08.2013, p. 109-113.

Research output: Contribution to journalArticle

Prodam, F, Gasco, V, Caputo, M, Zavattaro, M, Pagano, L, Marzullo, P, Belcastro, S, Busti, A, Perino, C, Grottoli, S, Ghigo, E & Aimaretti, G 2013, 'Metabolic alterations in patients who develop traumatic brain injury (TBI)-induced hypopituitarism', Growth Hormone and IGF Research, vol. 23, no. 4, pp. 109-113. https://doi.org/10.1016/j.ghir.2013.04.001
Prodam, F. ; Gasco, V. ; Caputo, M. ; Zavattaro, M. ; Pagano, L. ; Marzullo, P. ; Belcastro, S. ; Busti, A. ; Perino, C. ; Grottoli, S. ; Ghigo, E. ; Aimaretti, G. / Metabolic alterations in patients who develop traumatic brain injury (TBI)-induced hypopituitarism. In: Growth Hormone and IGF Research. 2013 ; Vol. 23, No. 4. pp. 109-113.
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