Metabolic and anthropometric changes in early breast cancer patients receiving adjuvant therapy

Grazia Arpino, Carmine De Angelis, Giuseppe Buono, Annamaria Colao, Mario Giuliano, Simona Malgieri, Stefania Cicala, Michelino De Laurentiis, Antonello Accurso, Anna Crispo, Gennaro Limite, Rossella Lauria, Bianca Maria Veneziani, Valeria Forestieri, Dario Bruzzese, Sabino De Placido

Research output: Contribution to journalArticlepeer-review


Weight gain and metabolic changes have been related to survival of early breast cancer patients (EBC). ‘’However, factors influencing metabolism post-diagnosis are not fully understood. We measured anthropometric [body mass index (BMI), body weight, waist and hip circumferences, and waist-to-hip ratio] and metabolic (levels of insulin, glucose, H1Ac, total, HDL, and LDL cholesterol, triglycerides, and the homeostasis model assessment score [HOMA]) parameters in 433 pre- and post-menopausal women with EBC at diagnosis and 3, 6, 9, 12, and 24 months thereafter. At diagnosis, compared with post-menopausal women, pre-menopausal patients were more likely to be leaner and to have a lower BMI, smaller waist and hip circumferences, and waist-to-hip ratio. They had also lower glucose, HbA1c, and triglyceride levels and a lower HOMA score. Furthermore, they were more likely to have an estrogen- and/or progesterone-positive tumor and a higher proliferating breast cancer. During the first two post-diagnosis years, all women showed a significant increase of weight (+0.72 kg/year, P 

Original languageEnglish
Pages (from-to)127-132
Number of pages6
JournalBreast Cancer Research and Treatment
Issue number1
Publication statusPublished - Sep 30 2015


  • Adjuvant therapy
  • Body weight and composition
  • Breast cancer
  • Glucose and lipid metabolism
  • Menopausal status

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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