Metabolic and anthropometric changes in early breast cancer patients receiving adjuvant therapy

Grazia Arpino, Carmine De Angelis, Giuseppe Buono, Annamaria Colao, Mario Giuliano, Simona Malgieri, Stefania Cicala, Michelino De Laurentiis, Antonello Accurso, Anna Crispo, Gennaro Limite, Rossella Lauria, Bianca Maria Veneziani, Valeria Forestieri, Dario Bruzzese, Sabino De Placido

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Weight gain and metabolic changes have been related to survival of early breast cancer patients (EBC). ‘’However, factors influencing metabolism post-diagnosis are not fully understood. We measured anthropometric [body mass index (BMI), body weight, waist and hip circumferences, and waist-to-hip ratio] and metabolic (levels of insulin, glucose, H1Ac, total, HDL, and LDL cholesterol, triglycerides, and the homeostasis model assessment score [HOMA]) parameters in 433 pre- and post-menopausal women with EBC at diagnosis and 3, 6, 9, 12, and 24 months thereafter. At diagnosis, compared with post-menopausal women, pre-menopausal patients were more likely to be leaner and to have a lower BMI, smaller waist and hip circumferences, and waist-to-hip ratio. They had also lower glucose, HbA1c, and triglyceride levels and a lower HOMA score. Furthermore, they were more likely to have an estrogen- and/or progesterone-positive tumor and a higher proliferating breast cancer. During the first two post-diagnosis years, all women showed a significant increase of weight (+0.72 kg/year, P 

Original languageEnglish
Pages (from-to)127-132
Number of pages6
JournalBreast Cancer Research and Treatment
Volume154
Issue number1
DOIs
Publication statusPublished - Sep 30 2015

Fingerprint

Breast Neoplasms
Waist-Hip Ratio
Waist Circumference
Hip
Body Mass Index
Homeostasis
Glucose
Therapeutics
LDL Cholesterol
HDL Cholesterol
Weight Gain
Progesterone
Estrogens
Triglycerides
Body Weight
Insulin
Weights and Measures
Survival
Neoplasms
low density lipoprotein triglyceride

Keywords

  • Adjuvant therapy
  • Body weight and composition
  • Breast cancer
  • Glucose and lipid metabolism
  • Menopausal status

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Arpino, G., De Angelis, C., Buono, G., Colao, A., Giuliano, M., Malgieri, S., ... De Placido, S. (2015). Metabolic and anthropometric changes in early breast cancer patients receiving adjuvant therapy. Breast Cancer Research and Treatment, 154(1), 127-132. https://doi.org/10.1007/s10549-015-3586-x

Metabolic and anthropometric changes in early breast cancer patients receiving adjuvant therapy. / Arpino, Grazia; De Angelis, Carmine; Buono, Giuseppe; Colao, Annamaria; Giuliano, Mario; Malgieri, Simona; Cicala, Stefania; De Laurentiis, Michelino; Accurso, Antonello; Crispo, Anna; Limite, Gennaro; Lauria, Rossella; Veneziani, Bianca Maria; Forestieri, Valeria; Bruzzese, Dario; De Placido, Sabino.

In: Breast Cancer Research and Treatment, Vol. 154, No. 1, 30.09.2015, p. 127-132.

Research output: Contribution to journalArticle

Arpino, G, De Angelis, C, Buono, G, Colao, A, Giuliano, M, Malgieri, S, Cicala, S, De Laurentiis, M, Accurso, A, Crispo, A, Limite, G, Lauria, R, Veneziani, BM, Forestieri, V, Bruzzese, D & De Placido, S 2015, 'Metabolic and anthropometric changes in early breast cancer patients receiving adjuvant therapy', Breast Cancer Research and Treatment, vol. 154, no. 1, pp. 127-132. https://doi.org/10.1007/s10549-015-3586-x
Arpino, Grazia ; De Angelis, Carmine ; Buono, Giuseppe ; Colao, Annamaria ; Giuliano, Mario ; Malgieri, Simona ; Cicala, Stefania ; De Laurentiis, Michelino ; Accurso, Antonello ; Crispo, Anna ; Limite, Gennaro ; Lauria, Rossella ; Veneziani, Bianca Maria ; Forestieri, Valeria ; Bruzzese, Dario ; De Placido, Sabino. / Metabolic and anthropometric changes in early breast cancer patients receiving adjuvant therapy. In: Breast Cancer Research and Treatment. 2015 ; Vol. 154, No. 1. pp. 127-132.
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