Effetti metabolici e cardiovascolari della terapia antiretrovirale combinata in pazienti con infezione da HIV. Rassegna sistematica della letteratura.

Translated title of the contribution: [Metabolic and cardiovascular effects of combined antiretroviral therapy in patients with HIV infection. Systematic review of literature].

Laura Casaretti, Stefania Paolillo, Roberto Formisano, Ada Bologna, Giacomo Mattiello, Sirio Conte, Laura Petraglia, Francesco Lo Ludice, Irma Fabiani, Anna Paola Cirillo, Alice Vitagliano, Francesco Gambardella, Giuseppe Luca della Ratta, Pasquale Perrone Filardi

Research output: Contribution to journalArticlepeer-review

Abstract

In HIV infected patients an increased incidence of cardiac events has been reported since the introduction of highly active antiretroviral therapy (HAART). Antiretroviral drugs' regimens are, in fact, associated with several metabolic side effects, such as dyslipidemia, impaired glucose metabolism and abnormal body fat distribution, that increase cardiovascular risk of HIV subjects. In addition, HIV infection itself, the chronic inflammatory status and the frequent presence in this population of traditional risk factors contribute to an higher incidence of cardio and cerebrovascular events. In last years several studies showed the occurrence of carotid vascular impairment in patients treated with protease inhibitors (PI). Similarly the DAD Study reported an increase of 26% of the risk of myocardial infarction in patients on HAART and that this risk was independently associated with longer exposure to PI, after multivariate adjustments. A correct evaluation of the metabolic status before starting HAART and an adequate control of drugs-related metabolic abnormalities may reduce the incidence of cardiac events and still improve HIV patients prognosis. This review will focus on the metabolic effects of antiretroviral drugs and on the contribution of combination antiretroviral therapy on cardiovascular risk.

Translated title of the contribution[Metabolic and cardiovascular effects of combined antiretroviral therapy in patients with HIV infection. Systematic review of literature].
Original languageItalian
Pages (from-to)175-182
Number of pages8
JournalMonaldi Archives for Chest Disease - Cardiac Series
Volume76
Issue number4
Publication statusPublished - Dec 2011

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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