Metabolic and hemodynamic effects of peptide leukotriene C4 and D4 in man

C. Vigorito, A. Giordano, R. Cirillo, A. Genovese, F. Rengo, G. Marone

Research output: Contribution to journalArticlepeer-review


The time course of the effects of intravenous or intracoronary administration of peptide leukotrienes on metabolic parameters and on systemic and coronary hemodynamics was evaluated in 15 patients with normal coronary arteries. Peptide leukotriene C4 (2 nmol given as a bolus intravenous injection) induced an early fall (at 2 min) in mean arterial pressure (P4 administration. In contrast, at 10 min post leukotriene C4, with coronary blood flow and myocardial oxygen consumption unchanged, an increase in coronary vascular resistance (P4. Peptide leukotriene D4 (3 nmol, given in the left coronary artery) induced an early (20 s) and transient fall in mean arterial pressure (P

Original languageEnglish
Pages (from-to)178-184
Number of pages7
JournalInternational Journal of Clinical & Laboratory Research
Issue number3
Publication statusPublished - Sep 1997


  • Coronary blood flow
  • Leukotriene C
  • Leukotriene D

ASJC Scopus subject areas

  • Clinical Biochemistry


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