Metabolic and hemodynamic effects of peptide leukotriene C4 and D4 in man

C. Vigorito; A. Giordano; R. Cirillo; A. Genovese; F. Rengo; G. Marone

Metabolic and hemodynamic effects of peptide leukotriene C₄ and D₄ in man

C. Vigorito, A. Giordano, R. Cirillo, A. Genovese, F. Rengo, G. Marone

Istituti Clinici Scientifici Maugeri Spa – Società Benefit

Research output: Contribution to journal › Article › peer-review

Abstract

The time course of the effects of intravenous or intracoronary administration of peptide leukotrienes on metabolic parameters and on systemic and coronary hemodynamics was evaluated in 15 patients with normal coronary arteries. Peptide leukotriene C₄ (2 nmol given as a bolus intravenous injection) induced an early fall (at 2 min) in mean arterial pressure (P4 administration. In contrast, at 10 min post leukotriene C₄, with coronary blood flow and myocardial oxygen consumption unchanged, an increase in coronary vascular resistance (P4. Peptide leukotriene D₄ (3 nmol, given in the left coronary artery) induced an early (20 s) and transient fall in mean arterial pressure (P

Original language	English
Pages (from-to)	178-184
Number of pages	7
Journal	International Journal of Clinical & Laboratory Research
Volume	27
Issue number	3
Publication status	Published - Sep 1997

Keywords

Coronary blood flow
Leukotriene C
Leukotriene D

ASJC Scopus subject areas

Clinical Biochemistry

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abstract = "The time course of the effects of intravenous or intracoronary administration of peptide leukotrienes on metabolic parameters and on systemic and coronary hemodynamics was evaluated in 15 patients with normal coronary arteries. Peptide leukotriene C4 (2 nmol given as a bolus intravenous injection) induced an early fall (at 2 min) in mean arterial pressure (P4 administration. In contrast, at 10 min post leukotriene C4, with coronary blood flow and myocardial oxygen consumption unchanged, an increase in coronary vascular resistance (P4. Peptide leukotriene D4 (3 nmol, given in the left coronary artery) induced an early (20 s) and transient fall in mean arterial pressure (P",

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AU - Cirillo, R.

AU - Genovese, A.

AU - Rengo, F.

AU - Marone, G.

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KW - Leukotriene D

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