Metabolic and immunological features of the failing islet-transplanted patient

Paolo Fiorina, Andrea Vergani, Alessandra Petrelli, Francesca D'Addio, Lucilla Monti, Reza Abdi, Emanuele Bosi, Paola Maffi, Antonio Secchi

Research output: Contribution to journalArticle

Abstract

OBJECTIVE -This retrospective study was designed to identify metabolic and immune predictors of early islet allograft failure. RESEARCH DESIGN AND METHODS -We measured several metabolic and immunological markers at the time of pretransplant and several time points posttransplantation in 17 patients with long-term functioning graft (long fx) and 20 patients with short-term functioning graft (short fx). RESULTS -The short fx group showed higher insulin resistance, altered proinsulin processing, lower soluble interleukin-2 receptor (sIL-2r) (marker of T-cell activation), and higher soluble FasL (marker of apoptosis) during the entire follow-up, particularly at time of failure. CONCLUSIONS -Patients who experienced an early failure of islet allograft showed specific metabolic and immunological signs long before islet failure.

Original languageEnglish
Pages (from-to)436-438
Number of pages3
JournalDiabetes Care
Volume31
Issue number3
DOIs
Publication statusPublished - Mar 2008

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ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialised Nursing

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