TY - JOUR
T1 - Metabolic and vascular effect of progestins in post-menopausal women
T2 - Implications for cardioprotection
AU - Rosano, Giuseppe M C
AU - Vitale, Cristiana
AU - Silvestri, Antonello
AU - Fini, Massimo
PY - 2003/12/10
Y1 - 2003/12/10
N2 - Estrogen therapy causes changes in a variety of cardiovascular risk factors, including insulin resistance, lipoprotein profile, haemostasis, coronary atherosclerosis and vascular reactive, that suggest a potential cardioprotective effect in postmenopausal women. With respect to the role of adjunctive progestins, currently available data suggest that the cardiovascular effects may differ depending on the type, dosage and route of administration of the progestin. Androgenic progestins antagonise the favourable cardiovascular effect of estrogens, whilst non-androgenic progestins do not impair, or may even enhance, the beneficial effect of estrogens. Therefore, less androgenic progestins would appear to be the agent of choice for combined hormone therapy in postmenopausal women with cardiovascular risk factors.
AB - Estrogen therapy causes changes in a variety of cardiovascular risk factors, including insulin resistance, lipoprotein profile, haemostasis, coronary atherosclerosis and vascular reactive, that suggest a potential cardioprotective effect in postmenopausal women. With respect to the role of adjunctive progestins, currently available data suggest that the cardiovascular effects may differ depending on the type, dosage and route of administration of the progestin. Androgenic progestins antagonise the favourable cardiovascular effect of estrogens, whilst non-androgenic progestins do not impair, or may even enhance, the beneficial effect of estrogens. Therefore, less androgenic progestins would appear to be the agent of choice for combined hormone therapy in postmenopausal women with cardiovascular risk factors.
KW - Cardioprotection
KW - Diabetes
KW - Endothelial function
KW - Hormone replacement therapy
KW - Metabolic and vascular effect
KW - Progestins
UR - http://www.scopus.com/inward/record.url?scp=0345167225&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0345167225&partnerID=8YFLogxK
U2 - 10.1016/j.maturitas.2003.09.015
DO - 10.1016/j.maturitas.2003.09.015
M3 - Article
C2 - 14670642
AN - SCOPUS:0345167225
VL - 46
JO - Maturitas
JF - Maturitas
SN - 0378-5122
IS - SUPPL. 1
ER -