Metabolic assessment after simultaneous pancreas-kidney transplantation

J. Malaise, A. Secchi, R. Caldara, G. Tydén, J. Sandberg, D. Van Ophem, J. P. Squifflet

Research output: Contribution to journalArticle

Abstract

Simultaneous pancreas-kidney (SPK) transplantation has become a standard therapy for patients with type 1 diabetes and end-stage renal disease. We analyzed metabolic data in this clinical setting under tacrolimus- versus cyclosporine microemulsion (ME)-based immunosuppressive therapy. Patients and methods. We analyzed 205 patients enrolled in the Euro-SPK001 study for fasting blood glucose, fasting C peptide, glycated hemoglobin (HbA1c), blood lipids (total cholesterol and triglycerides), and pancreatic enzymes at regular intervals during the study. We compared blood pressure values with target levels for diabetic patients published by the European Society for Hypertension. Results. Throughout the study, HbA1c and fasting C peptide levels were within the normal range in the two groups. Fasting blood glucose was higher during the first 2 months posttransplant in the tacrolimus group than in the cyclosporine-ME group, but no differences were seen thereafter. From month 2 posttransplant, mean levels of total cholesterol were significantly lower among patients receiving tacrolimus than those in the cyclosporine-ME group. In addition, patients receiving cyclosporine-ME showed serologic features of mild pancreatitis with elevated blood amylase and lipase levels during the first 6 months posttransplant. The two regimens were comparable with respect to hypertension, but target levels were reached in only 50% of the patients. Conclusion. Except for lipid profiles, no major differences in metabolic effects or blood pressure control were observed among SPK transplant patients receiving immunosuppression based on tacrolimus versus cyclosporine-ME. In view of the potential risk of hypertension, antihypertensive strategies should be implemented for all patients.

Original languageEnglish
Pages (from-to)2851-2852
Number of pages2
JournalTransplantation Proceedings
Volume37
Issue number6
DOIs
Publication statusPublished - 2005

ASJC Scopus subject areas

  • Surgery
  • Transplantation

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    Malaise, J., Secchi, A., Caldara, R., Tydén, G., Sandberg, J., Van Ophem, D., & Squifflet, J. P. (2005). Metabolic assessment after simultaneous pancreas-kidney transplantation. Transplantation Proceedings, 37(6), 2851-2852. https://doi.org/10.1016/j.transproceed.2005.05.025