Metabolic Bone Disease in Patients with Malabsorption

Catherine M. Phan, Giuseppe Guglielmi

Research output: Contribution to journalArticlepeer-review


Chronic inflammation and malabsorption in gastrointestinal disease can cause bone metabolism alterations and bone mineral loss in children and adults. Gastrointestinal disease is often forgotten as a cause of osteoporosis, osteopenia, or osteomalacia. The etiology of pathologic bone alterations in gastrointestinal disease is multifactorial. Bone alterations were thought to result simply from intestinal malabsorption, but a more complex interaction between cytokines and local/systemic factors influencing bone formation and resorption is envisaged. This review provides an updated discussion on bone alterations in patients with malabsorption due to celiac disease or inflammatory bowel disease.

Original languageEnglish
Pages (from-to)369-375
Number of pages7
JournalSeminars in Musculoskeletal Radiology
Issue number4
Publication statusPublished - Sep 1 2016


  • bone densitometry
  • celiac disease/inflammatory bowel disease
  • malabsorption
  • osteomalacia
  • osteoporosis

ASJC Scopus subject areas

  • Medicine(all)
  • Orthopedics and Sports Medicine
  • Radiology Nuclear Medicine and imaging


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