TY - JOUR
T1 - Metabolic bone diseases in patients after allogeneic hematopoietic stem cell transplantation
T2 - Report from the Consensus Conference on Clinical Practice in chronic graft-versus-host disease
AU - Hautmann, Anke Heidewig
AU - Elad, Sharon
AU - Lawitschka, Anita
AU - Greinix, Hildegard
AU - Bertz, Hartmut
AU - Halter, Joerg
AU - Faraci, Maura
AU - Christian Hofbauer, Lorenz
AU - Lee, Stephanie
AU - Wolff, Daniel
AU - Holler, Ernst
PY - 2011/9
Y1 - 2011/9
N2 - With improved outcome of allogeneic stem cell transplantation (allo-SCT) for hematologic malignancies, long-term complications gain greater importance. Skeletal complications such as osteoporosis or avascular necrosis (AVN) occur frequently in allogeneic recipients with a cumulative incidence of diminished bone mineral density of 24-50% between 2 and 12 months after allo-SCT and a cumulative incidence of AVN in as many as 19% of patients 3 years after allo-SCT. Here, we present a review as part of the German, Austrian, and Swiss Consensus Conference on clinical practice in chronic graft-versus-host disease, held 2009 in Regensburg. The Consensus Conference aimed to achieve a consensus on the current evidence of diagnosis, prevention, and therapeutic options of late complications after allo-SCT summarizing and discussing the literature on these topics. In this report, we provide recommendations for metabolic bone diseases agreed upon by the working party. This includes guidelines for diagnosis, prevention, and therapeutic options in patients with low bone mass or AVN.
AB - With improved outcome of allogeneic stem cell transplantation (allo-SCT) for hematologic malignancies, long-term complications gain greater importance. Skeletal complications such as osteoporosis or avascular necrosis (AVN) occur frequently in allogeneic recipients with a cumulative incidence of diminished bone mineral density of 24-50% between 2 and 12 months after allo-SCT and a cumulative incidence of AVN in as many as 19% of patients 3 years after allo-SCT. Here, we present a review as part of the German, Austrian, and Swiss Consensus Conference on clinical practice in chronic graft-versus-host disease, held 2009 in Regensburg. The Consensus Conference aimed to achieve a consensus on the current evidence of diagnosis, prevention, and therapeutic options of late complications after allo-SCT summarizing and discussing the literature on these topics. In this report, we provide recommendations for metabolic bone diseases agreed upon by the working party. This includes guidelines for diagnosis, prevention, and therapeutic options in patients with low bone mass or AVN.
KW - allogeneic hematopoietic stem cell transplantation
KW - avascular necrosis
KW - bisphosphonates
KW - bone marrow transplantation
KW - malignancies and long-term complications
KW - osteoporosis
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U2 - 10.1111/j.1432-2277.2011.01264.x
DO - 10.1111/j.1432-2277.2011.01264.x
M3 - Article
C2 - 21557780
AN - SCOPUS:80051701525
VL - 24
SP - 867
EP - 879
JO - Transplant International
JF - Transplant International
SN - 0934-0874
IS - 9
ER -