Metabolic bone diseases in patients after allogeneic hematopoietic stem cell transplantation: Report from the Consensus Conference on Clinical Practice in chronic graft-versus-host disease

Anke Heidewig Hautmann, Sharon Elad, Anita Lawitschka, Hildegard Greinix, Hartmut Bertz, Joerg Halter, Maura Faraci, Lorenz Christian Hofbauer, Stephanie Lee, Daniel Wolff, Ernst Holler

Research output: Contribution to journalArticlepeer-review

Abstract

With improved outcome of allogeneic stem cell transplantation (allo-SCT) for hematologic malignancies, long-term complications gain greater importance. Skeletal complications such as osteoporosis or avascular necrosis (AVN) occur frequently in allogeneic recipients with a cumulative incidence of diminished bone mineral density of 24-50% between 2 and 12 months after allo-SCT and a cumulative incidence of AVN in as many as 19% of patients 3 years after allo-SCT. Here, we present a review as part of the German, Austrian, and Swiss Consensus Conference on clinical practice in chronic graft-versus-host disease, held 2009 in Regensburg. The Consensus Conference aimed to achieve a consensus on the current evidence of diagnosis, prevention, and therapeutic options of late complications after allo-SCT summarizing and discussing the literature on these topics. In this report, we provide recommendations for metabolic bone diseases agreed upon by the working party. This includes guidelines for diagnosis, prevention, and therapeutic options in patients with low bone mass or AVN.

Original languageEnglish
Pages (from-to)867-879
Number of pages13
JournalTransplant International
Volume24
Issue number9
DOIs
Publication statusPublished - Sep 2011

Keywords

  • allogeneic hematopoietic stem cell transplantation
  • avascular necrosis
  • bisphosphonates
  • bone marrow transplantation
  • malignancies and long-term complications
  • osteoporosis

ASJC Scopus subject areas

  • Transplantation

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