Metabolic causes of epilepsy

Laura Papetti, Francesco Nicita, Stella Maiolo, Vincenzo Leuzzi, Alberto Spalice

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Inborn errors of metabolism comprise a large class of genetic diseases involving disorders of metabolism. Presentation is usually in the neonatal period or infancy but can occur at any time, even in adulthood. Seizures are frequent symptom in inborn errors of metabolism, with no specific seizure types or EEG signatures. The diagnosis of a genetic defect or an inborn error of metabolism often results in requests for a vast array of biochemical and molecular tests leading to an expensive workup. However a specific diagnosis of metabolic disorders in epileptic patients may provide the possibility of specific treatments that can improve seizures. In a few metabolic diseases, epilepsy responds to specific treatments based on diet or supplementation of cofactors (vitamin-responsive epilepsies), but for most of them specific treatment is unfortunately not available, and conventional antiepileptic drugs must be used, often with no satisfactory success. In this review we present an overview of metabolic epilepsies based on various criteria such as treatability, age of onset, seizure type, and pathogenetic background.

Original languageEnglish
Title of host publicationEpilepsy Towards the Next Decade: New Trends and Hopes in Epileptology
PublisherSpringer International Publishing
Pages71-99
Number of pages29
ISBN (Print)9783319122830, 9783319122823
DOIs
Publication statusPublished - Jan 1 2015

Fingerprint

Inborn Errors Metabolism
Epilepsy
Seizures
Inborn Genetic Diseases
Metabolic Diseases
Age of Onset
Vitamins
Anticonvulsants
Electroencephalography
Therapeutics
Diet

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)
  • Psychology(all)

Cite this

Papetti, L., Nicita, F., Maiolo, S., Leuzzi, V., & Spalice, A. (2015). Metabolic causes of epilepsy. In Epilepsy Towards the Next Decade: New Trends and Hopes in Epileptology (pp. 71-99). Springer International Publishing. https://doi.org/10.1007/978-3-319-12283-0_5

Metabolic causes of epilepsy. / Papetti, Laura; Nicita, Francesco; Maiolo, Stella; Leuzzi, Vincenzo; Spalice, Alberto.

Epilepsy Towards the Next Decade: New Trends and Hopes in Epileptology. Springer International Publishing, 2015. p. 71-99.

Research output: Chapter in Book/Report/Conference proceedingChapter

Papetti, L, Nicita, F, Maiolo, S, Leuzzi, V & Spalice, A 2015, Metabolic causes of epilepsy. in Epilepsy Towards the Next Decade: New Trends and Hopes in Epileptology. Springer International Publishing, pp. 71-99. https://doi.org/10.1007/978-3-319-12283-0_5
Papetti L, Nicita F, Maiolo S, Leuzzi V, Spalice A. Metabolic causes of epilepsy. In Epilepsy Towards the Next Decade: New Trends and Hopes in Epileptology. Springer International Publishing. 2015. p. 71-99 https://doi.org/10.1007/978-3-319-12283-0_5
Papetti, Laura ; Nicita, Francesco ; Maiolo, Stella ; Leuzzi, Vincenzo ; Spalice, Alberto. / Metabolic causes of epilepsy. Epilepsy Towards the Next Decade: New Trends and Hopes in Epileptology. Springer International Publishing, 2015. pp. 71-99
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