Metabolic changes in fibroblast adhesion sites induced by growth factors

I. J. Hiu, V. Liepkalns, B. Azzarone, A. Macieira-Coelho

Research output: Contribution to journalArticlepeer-review


The mechanisms involved in the association between membrane movements and the initiation of DNA synthesis were approached measuring the synthesis of membrane-associated substances after stimulation of resting phase cultures. The inducement of the division cycle by fresh serum, FGF and a growth factor produced during RSV infection, caused a decreased incorporation of glucosamine and SO4 into focal adhesion sites. The decreased incorporation of glucosamine occurred during the G1 period, remained at a plateau during S and increased back to initial levels when DNA synthesis declined; it was inversely related to the size of the fraction of cells that entered the division cycle.

Original languageEnglish
Pages (from-to)379-387
Number of pages9
JournalCell Biology International Reports
Issue number4
Publication statusPublished - 1985

ASJC Scopus subject areas

  • Cell Biology


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