TY - JOUR
T1 - Metabolic changes in fibroblast adhesion sites induced by growth factors
AU - Hiu, I. J.
AU - Liepkalns, V.
AU - Azzarone, B.
AU - Macieira-Coelho, A.
PY - 1985
Y1 - 1985
N2 - The mechanisms involved in the association between membrane movements and the initiation of DNA synthesis were approached measuring the synthesis of membrane-associated substances after stimulation of resting phase cultures. The inducement of the division cycle by fresh serum, FGF and a growth factor produced during RSV infection, caused a decreased incorporation of glucosamine and SO4 into focal adhesion sites. The decreased incorporation of glucosamine occurred during the G1 period, remained at a plateau during S and increased back to initial levels when DNA synthesis declined; it was inversely related to the size of the fraction of cells that entered the division cycle.
AB - The mechanisms involved in the association between membrane movements and the initiation of DNA synthesis were approached measuring the synthesis of membrane-associated substances after stimulation of resting phase cultures. The inducement of the division cycle by fresh serum, FGF and a growth factor produced during RSV infection, caused a decreased incorporation of glucosamine and SO4 into focal adhesion sites. The decreased incorporation of glucosamine occurred during the G1 period, remained at a plateau during S and increased back to initial levels when DNA synthesis declined; it was inversely related to the size of the fraction of cells that entered the division cycle.
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U2 - 10.1016/0309-1651(85)90033-5
DO - 10.1016/0309-1651(85)90033-5
M3 - Article
C2 - 3995599
AN - SCOPUS:0022049444
VL - 9
SP - 379
EP - 387
JO - Cell Biology International Reports
JF - Cell Biology International Reports
SN - 0309-1651
IS - 4
ER -