Metabolic control may influence the increased superoxide generation in diabetic serum

A. Ceriello; D. Giugliano; A. Quatraro; P. Dello Russo; P. J. Lefebvre

Metabolic control may influence the increased superoxide generation in diabetic serum

A. Ceriello, D. Giugliano, A. Quatraro, P. Dello Russo, P. J. Lefebvre

IRCCS Multimedica

Research output: Contribution to journal › Article › peer-review

Abstract

Superoxide anion (O₂^-) generation in serum from 10 Type 1 diabetic patients and 10 normal subjects was measured ex vivo. The amount of O₂^- production was significantly increased in diabetic serum 0.41 ± 0.04 (±SD) vs 0.14 ± 0.04 μmol l^-1 min^-1, p <0.001) and correlated with fasting plasma glucose and glycosylated protein levels in both diabetic (r = 0.72, p <0.01, and r = 0.62, p <0.05) and normal (r = 0.75, p <0.01 and r = 0.64, p <0.05) subjects. Improved metabolic control in the diabetic patients was associated with a reduction of serum O₂^- production (0.28 ± 0.06 μmol l^-1 min^-1, p <0.01), but the correlation between O₂^- levels and fasting plasma glucose and glycosylated protein concentrations was retained (r = 0.86 and r = 0.72, respectively, both p <0.01).

Original language	English
Pages (from-to)	540-542
Number of pages	3
Journal	Diabetic Medicine
Volume	8
Issue number	6
Publication status	Published - 1991

Keywords

Blood glucose control
Diabetes
Free radicals
Superoxide

ASJC Scopus subject areas

Endocrinology
Endocrinology, Diabetes and Metabolism
Internal Medicine

Cite this

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title = "Metabolic control may influence the increased superoxide generation in diabetic serum",

abstract = "Superoxide anion (O2-) generation in serum from 10 Type 1 diabetic patients and 10 normal subjects was measured ex vivo. The amount of O2- production was significantly increased in diabetic serum 0.41 ± 0.04 (±SD) vs 0.14 ± 0.04 μmol l-1 min-1, p <0.001) and correlated with fasting plasma glucose and glycosylated protein levels in both diabetic (r = 0.72, p <0.01, and r = 0.62, p <0.05) and normal (r = 0.75, p <0.01 and r = 0.64, p <0.05) subjects. Improved metabolic control in the diabetic patients was associated with a reduction of serum O2- production (0.28 ± 0.06 μmol l-1 min-1, p <0.01), but the correlation between O2- levels and fasting plasma glucose and glycosylated protein concentrations was retained (r = 0.86 and r = 0.72, respectively, both p <0.01).",

keywords = "Blood glucose control, Diabetes, Free radicals, Superoxide",

author = "A. Ceriello and D. Giugliano and A. Quatraro and {Dello Russo}, P. and Lefebvre, {P. J.}",

year = "1991",

language = "English",

volume = "8",

pages = "540--542",

journal = "Diabetic Medicine",

issn = "0742-3071",

publisher = "Wiley-Blackwell",

number = "6",

}

TY - JOUR

T1 - Metabolic control may influence the increased superoxide generation in diabetic serum

AU - Ceriello, A.

AU - Giugliano, D.

AU - Quatraro, A.

AU - Dello Russo, P.

AU - Lefebvre, P. J.

PY - 1991

Y1 - 1991

N2 - Superoxide anion (O2-) generation in serum from 10 Type 1 diabetic patients and 10 normal subjects was measured ex vivo. The amount of O2- production was significantly increased in diabetic serum 0.41 ± 0.04 (±SD) vs 0.14 ± 0.04 μmol l-1 min-1, p <0.001) and correlated with fasting plasma glucose and glycosylated protein levels in both diabetic (r = 0.72, p <0.01, and r = 0.62, p <0.05) and normal (r = 0.75, p <0.01 and r = 0.64, p <0.05) subjects. Improved metabolic control in the diabetic patients was associated with a reduction of serum O2- production (0.28 ± 0.06 μmol l-1 min-1, p <0.01), but the correlation between O2- levels and fasting plasma glucose and glycosylated protein concentrations was retained (r = 0.86 and r = 0.72, respectively, both p <0.01).

AB - Superoxide anion (O2-) generation in serum from 10 Type 1 diabetic patients and 10 normal subjects was measured ex vivo. The amount of O2- production was significantly increased in diabetic serum 0.41 ± 0.04 (±SD) vs 0.14 ± 0.04 μmol l-1 min-1, p <0.001) and correlated with fasting plasma glucose and glycosylated protein levels in both diabetic (r = 0.72, p <0.01, and r = 0.62, p <0.05) and normal (r = 0.75, p <0.01 and r = 0.64, p <0.05) subjects. Improved metabolic control in the diabetic patients was associated with a reduction of serum O2- production (0.28 ± 0.06 μmol l-1 min-1, p <0.01), but the correlation between O2- levels and fasting plasma glucose and glycosylated protein concentrations was retained (r = 0.86 and r = 0.72, respectively, both p <0.01).

KW - Blood glucose control

KW - Diabetes

KW - Free radicals

KW - Superoxide

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M3 - Article

C2 - 1653676

AN - SCOPUS:0025742638

VL - 8

SP - 540

EP - 542

JO - Diabetic Medicine

JF - Diabetic Medicine

SN - 0742-3071

IS - 6

ER -

Metabolic control may influence the increased superoxide generation in diabetic serum

Abstract

Keywords

ASJC Scopus subject areas

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