Abstract
Superoxide anion (O2-) generation in serum from 10 Type 1 diabetic patients and 10 normal subjects was measured ex vivo. The amount of O2- production was significantly increased in diabetic serum 0.41 ± 0.04 (±SD) vs 0.14 ± 0.04 μmol l-1 min-1, p <0.001) and correlated with fasting plasma glucose and glycosylated protein levels in both diabetic (r = 0.72, p <0.01, and r = 0.62, p <0.05) and normal (r = 0.75, p <0.01 and r = 0.64, p <0.05) subjects. Improved metabolic control in the diabetic patients was associated with a reduction of serum O2- production (0.28 ± 0.06 μmol l-1 min-1, p <0.01), but the correlation between O2- levels and fasting plasma glucose and glycosylated protein concentrations was retained (r = 0.86 and r = 0.72, respectively, both p <0.01).
Original language | English |
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Pages (from-to) | 540-542 |
Number of pages | 3 |
Journal | Diabetic Medicine |
Volume | 8 |
Issue number | 6 |
Publication status | Published - 1991 |
Keywords
- Blood glucose control
- Diabetes
- Free radicals
- Superoxide
ASJC Scopus subject areas
- Endocrinology
- Endocrinology, Diabetes and Metabolism
- Internal Medicine