Metabolic control may influence the increased superoxide generation in diabetic serum

A. Ceriello, D. Giugliano, A. Quatraro, P. Dello Russo, P. J. Lefebvre

Research output: Contribution to journalArticlepeer-review

Abstract

Superoxide anion (O2-) generation in serum from 10 Type 1 diabetic patients and 10 normal subjects was measured ex vivo. The amount of O2- production was significantly increased in diabetic serum 0.41 ± 0.04 (±SD) vs 0.14 ± 0.04 μmol l-1 min-1, p <0.001) and correlated with fasting plasma glucose and glycosylated protein levels in both diabetic (r = 0.72, p <0.01, and r = 0.62, p <0.05) and normal (r = 0.75, p <0.01 and r = 0.64, p <0.05) subjects. Improved metabolic control in the diabetic patients was associated with a reduction of serum O2- production (0.28 ± 0.06 μmol l-1 min-1, p <0.01), but the correlation between O2- levels and fasting plasma glucose and glycosylated protein concentrations was retained (r = 0.86 and r = 0.72, respectively, both p <0.01).

Original languageEnglish
Pages (from-to)540-542
Number of pages3
JournalDiabetic Medicine
Volume8
Issue number6
Publication statusPublished - 1991

Keywords

  • Blood glucose control
  • Diabetes
  • Free radicals
  • Superoxide

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

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