Metabolic control of immune tolerance in health and autoimmunity

Fortunata Carbone, Claudia La Rocca, Paola De Candia, Claudio Procaccini, Alessandra Colamatteo, Teresa Micillo, Veronica De Rosa, Giuseppe Matarese

Research output: Contribution to journalReview articlepeer-review


The filed that links immunity and metabolism is rapidly expanding. The adipose tissue, by secreting a series of immune regulators called adipokines, represents the common mediator linking metabolic processes and immune system functions. The dysregulation of adipokine secretion, occurring in obese individuals or in conditions of malnutrition or dietary restriction, affects the activity of immune cells resulting in inflammatory autoimmune responses or increased susceptibility to infectious diseases. Alterations of cell metabolism that characterize several autoimmune diseases strongly support the idea that the immune tolerance is also regulated by metabolic pathways. The comprehension of the molecular mechanisms underlying these alterations may lead to the development of novel therapeutic strategies to control immune cell differentiation and function in conditions of autoimmunity.

Original languageEnglish
Pages (from-to)491-504
Number of pages14
JournalSeminars in Immunology
Issue number5
Publication statusPublished - Oct 1 2016


  • Autoimmune diseases
  • Immune tolerance
  • Malnutrition
  • Metabolism
  • Obesity

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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