Metabolic control of immune tolerance in health and autoimmunity

Fortunata Carbone; Claudia La Rocca; Paola De Candia; Claudio Procaccini; Alessandra Colamatteo; Teresa Micillo; Veronica De Rosa; Giuseppe Matarese

doi:10.1016/j.smim.2016.09.006

Metabolic control of immune tolerance in health and autoimmunity

Fortunata Carbone, Claudia La Rocca, Paola De Candia, Claudio Procaccini, Alessandra Colamatteo, Teresa Micillo, Veronica De Rosa, Giuseppe Matarese

IRCCS Multimedica

Research output: Contribution to journal › Review article › peer-review

Abstract

The filed that links immunity and metabolism is rapidly expanding. The adipose tissue, by secreting a series of immune regulators called adipokines, represents the common mediator linking metabolic processes and immune system functions. The dysregulation of adipokine secretion, occurring in obese individuals or in conditions of malnutrition or dietary restriction, affects the activity of immune cells resulting in inflammatory autoimmune responses or increased susceptibility to infectious diseases. Alterations of cell metabolism that characterize several autoimmune diseases strongly support the idea that the immune tolerance is also regulated by metabolic pathways. The comprehension of the molecular mechanisms underlying these alterations may lead to the development of novel therapeutic strategies to control immune cell differentiation and function in conditions of autoimmunity.

Original language	English
Pages (from-to)	491-504
Number of pages	14
Journal	Seminars in Immunology
Volume	28
Issue number	5
DOIs	https://doi.org/10.1016/j.smim.2016.09.006
Publication status	Published - Oct 1 2016

Keywords

Autoimmune diseases
Immune tolerance
Malnutrition
Metabolism
Obesity

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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title = "Metabolic control of immune tolerance in health and autoimmunity",

abstract = "The filed that links immunity and metabolism is rapidly expanding. The adipose tissue, by secreting a series of immune regulators called adipokines, represents the common mediator linking metabolic processes and immune system functions. The dysregulation of adipokine secretion, occurring in obese individuals or in conditions of malnutrition or dietary restriction, affects the activity of immune cells resulting in inflammatory autoimmune responses or increased susceptibility to infectious diseases. Alterations of cell metabolism that characterize several autoimmune diseases strongly support the idea that the immune tolerance is also regulated by metabolic pathways. The comprehension of the molecular mechanisms underlying these alterations may lead to the development of novel therapeutic strategies to control immune cell differentiation and function in conditions of autoimmunity.",

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AU - Carbone, Fortunata

AU - La Rocca, Claudia

AU - De Candia, Paola

AU - Procaccini, Claudio

AU - Colamatteo, Alessandra

AU - Micillo, Teresa

AU - De Rosa, Veronica

AU - Matarese, Giuseppe

PY - 2016/10/1

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AB - The filed that links immunity and metabolism is rapidly expanding. The adipose tissue, by secreting a series of immune regulators called adipokines, represents the common mediator linking metabolic processes and immune system functions. The dysregulation of adipokine secretion, occurring in obese individuals or in conditions of malnutrition or dietary restriction, affects the activity of immune cells resulting in inflammatory autoimmune responses or increased susceptibility to infectious diseases. Alterations of cell metabolism that characterize several autoimmune diseases strongly support the idea that the immune tolerance is also regulated by metabolic pathways. The comprehension of the molecular mechanisms underlying these alterations may lead to the development of novel therapeutic strategies to control immune cell differentiation and function in conditions of autoimmunity.

KW - Autoimmune diseases

KW - Immune tolerance

KW - Malnutrition

KW - Metabolism

KW - Obesity

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Metabolic control of immune tolerance in health and autoimmunity

Abstract

Keywords

ASJC Scopus subject areas

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