Metabolic disorders across hepatocellular carcinoma in Italy

F. Morisco, M. Guarino, M.R. Valvano, F. Auriemma, F. Farinati, E.G. Giannini, F. Ciccarese, F. Tovoli, G.L. Rapaccini, M. Di Marco, E. Caturelli, M. Zoli, F. Borzio, R. Sacco, G. Cabibbo, M. Felder, L. Benvengù, A. Gasbarrini, G. Svegliati Baroni, F.G. FoschiE. Biasini, A. Masotto, R. Virdone, F. Marra, N. Caporaso, F. Trevisani, A. Sessa, F. Marafatto, G. Peserico, C. Pozzan, M. Brunacci, A. Moscatelli, G. Pellegatta, V. Savarino, P. Del Poggio, S. Olmi, N. de Matthaeis, C. Balsamo, E. Vavassori, P. Roselli, V. Lauria, G. Pelecca, V. Mismas, M. Rossi, S. Attardo, G. Cavani, A. Mega, E. Rinninella, A. Ortolani, A. Casadei Gardini

Research output: Contribution to journalArticlepeer-review


Background: Metabolic disorders are well-known risk factors for HCC. Conversely, their impact on the natural history of HCC is not established. This study aimed at evaluating the impact of metabolic disorders on clinical features, treatment and survival of HCC patients regardless of its aetiology. Methods: We analysed the ITA.LI.CA database regarding 839 HCC patients prospectively collected. The following metabolic features were analysed: BMI, diabetes, arterial hypertension, hypercholesterolaemia and hypertriglyceridaemia. According to these features, patients were divided into 3 groups: 0-1, 2 and 3-5 metabolic features. Results: As compared with patients with 0-1 metabolic features, patients with 3-5 features showed lower percentage of HCC diagnosis on surveillance (P =.021), larger tumours (P =.038), better liver function (higher percentage of Child-Pugh class A [P =.007] and MELD 
Original languageEnglish
Pages (from-to)2028-2039
Number of pages12
JournalLiver International
Issue number11
Publication statusPublished - 2018


  • alpha fetoprotein
  • antidiabetic agent
  • antihypertensive agent
  • antivirus agent
  • creatinine
  • hepatitis B surface antigen
  • lead
  • sodium
  • sorafenib, adult
  • aged
  • Article
  • body mass
  • cancer diagnosis
  • cancer staging
  • cancer survival
  • Child Pugh score
  • clinical evaluation
  • clinical feature
  • comparative study
  • controlled study
  • diabetes mellitus
  • diabetic patient
  • disease surveillance
  • female
  • human
  • hypercholesterolemia
  • hypertension
  • hypertriglyceridemia
  • Italy
  • liver cell carcinoma
  • liver function
  • liver metastasis
  • major clinical study
  • male
  • metabolic disorder
  • Model For End Stage Liver Disease Score
  • overall survival
  • portal vein thrombosis
  • prospective study
  • regional perfusion
  • retrospective study
  • sensitivity analysis
  • treatment indication
  • tumor volume


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