Metabolic disturbances in chronic heart failure: A case for the "macho" approach with testosterone?!

Mitja Lainscak, Wolfram Doehner, Stefan D. Anker

Research output: Contribution to journalArticlepeer-review

Abstract

Chronic heart failure (CHF) primarily affects the cardiovascular system. In addition, there is strong evidence that CHF is a complex metabolic disorder. Metabolic abnormalities include insulin resistance and lack of anabolic hormone activity. To date there have been few interventional trials targeting insulin sensitivity. A recent study suggests a link between testosterone therapy and improvements in insulin sensitivity, measured using the homeostatic model assessment (HOMA-IR). We discuss this study in detail. Further studies are needed to substantiate this link and to generally explore the value of testosterone therapy in CHF patients.

Original languageEnglish
Pages (from-to)2-3
Number of pages2
JournalEuropean Journal of Heart Failure
Volume9
Issue number1
DOIs
Publication statusPublished - Jan 2007

Keywords

  • Cachexia
  • Insulin resistance
  • Testosterone

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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