Abstract
OBJECTIVE - To assess differences between the effects of aerobic and resistance training on HbA 1c (primary outcome) and several metabolic risk factors in subjects with type 2 diabetes, and to identify predictors of exercise-induced metabolic improvement. RESEARCH DESIGN AND METHODS - Type 2 diabetic patients (n = 40) were randomly assigned to aerobic training or resistance training. Before and after 4 months of intervention, metabolic phenotypes (including HbA 1c, glucose clamp-measured insulin sensitivity, and oral glucose tolerance test-assessed β-cell function), body composition by dual-energy X-ray absorptiometry, visceral (VAT) and subcutaneous (SAT) adipose tissue by magnetic resonance imaging, cardiorespiratory fitness, and muscular strength were measured. RESULTS - After training, increase in peak oxygen consumption (VO 2peak) was greater in the aerobic group (time-by-group interaction P = 0.045), whereas increase in strength was greater in the resistance group (time-by-group interaction P <0.0001). HbA 1c was similarly reduced in both groups (-0.40% [95% CI -0.61 to -0.18] vs. -0.35% [-0.59 to -0.10], respectively). Total and truncal fat, VAT, and SAT were also similarly reduced in both groups, whereas insulin sensitivity and lean limb mass were similarly increased. β-Cell function showed no significant changes. In multivariate analyses, improvement in HbA 1c after training was independently predicted by baseline HbA 1c and by changes in VO 2peak and truncal fat. CONCLUSIONS - Resistance training, similarly to aerobic training, improves metabolic features and insulin sensitivity and reduces abdominal fat in type 2 diabetic patients. Changes after training in VO 2peak and truncal fat may be primary determinants of exercise-induced metabolic improvement.
| Original language | English |
|---|---|
| Pages (from-to) | 676-682 |
| Number of pages | 7 |
| Journal | Diabetes Care |
| Volume | 35 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 2012 |
Fingerprint
ASJC Scopus subject areas
- Internal Medicine
- Endocrinology, Diabetes and Metabolism
- Advanced and Specialised Nursing
Cite this
Metabolic effects of aerobic training and resistance training in type 2 diabetic subjects : A randomized controlled trial (the RAED2 study). / Bacchi, Elisabetta; Negri, Carlo; Zanolin, Maria Elisabetta; Milanese, Chiara; Faccioli, Niccolò; Trombetta, Maddalena; Zoppini, Giacomo; Cevese, Antonio; Bonadonna, Riccardo C.; Schena, Federico; Bonora, Enzo; Lanza, Massimo; Moghetti, Paolo.
In: Diabetes Care, Vol. 35, No. 4, 04.2012, p. 676-682.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Metabolic effects of aerobic training and resistance training in type 2 diabetic subjects
T2 - A randomized controlled trial (the RAED2 study)
AU - Bacchi, Elisabetta
AU - Negri, Carlo
AU - Zanolin, Maria Elisabetta
AU - Milanese, Chiara
AU - Faccioli, Niccolò
AU - Trombetta, Maddalena
AU - Zoppini, Giacomo
AU - Cevese, Antonio
AU - Bonadonna, Riccardo C.
AU - Schena, Federico
AU - Bonora, Enzo
AU - Lanza, Massimo
AU - Moghetti, Paolo
PY - 2012/4
Y1 - 2012/4
N2 - OBJECTIVE - To assess differences between the effects of aerobic and resistance training on HbA 1c (primary outcome) and several metabolic risk factors in subjects with type 2 diabetes, and to identify predictors of exercise-induced metabolic improvement. RESEARCH DESIGN AND METHODS - Type 2 diabetic patients (n = 40) were randomly assigned to aerobic training or resistance training. Before and after 4 months of intervention, metabolic phenotypes (including HbA 1c, glucose clamp-measured insulin sensitivity, and oral glucose tolerance test-assessed β-cell function), body composition by dual-energy X-ray absorptiometry, visceral (VAT) and subcutaneous (SAT) adipose tissue by magnetic resonance imaging, cardiorespiratory fitness, and muscular strength were measured. RESULTS - After training, increase in peak oxygen consumption (VO 2peak) was greater in the aerobic group (time-by-group interaction P = 0.045), whereas increase in strength was greater in the resistance group (time-by-group interaction P <0.0001). HbA 1c was similarly reduced in both groups (-0.40% [95% CI -0.61 to -0.18] vs. -0.35% [-0.59 to -0.10], respectively). Total and truncal fat, VAT, and SAT were also similarly reduced in both groups, whereas insulin sensitivity and lean limb mass were similarly increased. β-Cell function showed no significant changes. In multivariate analyses, improvement in HbA 1c after training was independently predicted by baseline HbA 1c and by changes in VO 2peak and truncal fat. CONCLUSIONS - Resistance training, similarly to aerobic training, improves metabolic features and insulin sensitivity and reduces abdominal fat in type 2 diabetic patients. Changes after training in VO 2peak and truncal fat may be primary determinants of exercise-induced metabolic improvement.
AB - OBJECTIVE - To assess differences between the effects of aerobic and resistance training on HbA 1c (primary outcome) and several metabolic risk factors in subjects with type 2 diabetes, and to identify predictors of exercise-induced metabolic improvement. RESEARCH DESIGN AND METHODS - Type 2 diabetic patients (n = 40) were randomly assigned to aerobic training or resistance training. Before and after 4 months of intervention, metabolic phenotypes (including HbA 1c, glucose clamp-measured insulin sensitivity, and oral glucose tolerance test-assessed β-cell function), body composition by dual-energy X-ray absorptiometry, visceral (VAT) and subcutaneous (SAT) adipose tissue by magnetic resonance imaging, cardiorespiratory fitness, and muscular strength were measured. RESULTS - After training, increase in peak oxygen consumption (VO 2peak) was greater in the aerobic group (time-by-group interaction P = 0.045), whereas increase in strength was greater in the resistance group (time-by-group interaction P <0.0001). HbA 1c was similarly reduced in both groups (-0.40% [95% CI -0.61 to -0.18] vs. -0.35% [-0.59 to -0.10], respectively). Total and truncal fat, VAT, and SAT were also similarly reduced in both groups, whereas insulin sensitivity and lean limb mass were similarly increased. β-Cell function showed no significant changes. In multivariate analyses, improvement in HbA 1c after training was independently predicted by baseline HbA 1c and by changes in VO 2peak and truncal fat. CONCLUSIONS - Resistance training, similarly to aerobic training, improves metabolic features and insulin sensitivity and reduces abdominal fat in type 2 diabetic patients. Changes after training in VO 2peak and truncal fat may be primary determinants of exercise-induced metabolic improvement.
UR - http://www.scopus.com/inward/record.url?scp=84862067904&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84862067904&partnerID=8YFLogxK
U2 - 10.2337/dc11-1655
DO - 10.2337/dc11-1655
M3 - Article
C2 - 22344613
AN - SCOPUS:84862067904
VL - 35
SP - 676
EP - 682
JO - Diabetes Care
JF - Diabetes Care
SN - 1935-5548
IS - 4
ER -