Metabolic effects of anti-angiogenic therapy in tumors

Research output: Contribution to journalArticle

Abstract

Anti-angiogenic therapy has recently been added to the panel of cancer therapeutics, but predictive biomarkers of response are still not available. In animal models, anti-angiogenic therapy causes tumor starvation by increasing hypoxia and impairing nutrients supply. It is thus conceivable that angiogenesis inhibition causes remarkable metabolic perturbations in tumors, although they remain largely uncharted. We review here recent acquisitions about metabolic effects of angiogenesis blockade in tumors and discuss the possibility that some metabolic features of tumor cells - i.e. their dependency from glucose as primary energy substrate - might affect tumor responses to anti-VEGF treatment.

Original languageEnglish
Pages (from-to)925-931
Number of pages7
JournalBiochimie
Volume94
Issue number4
DOIs
Publication statusPublished - Apr 2012

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Keywords

  • Angiogenesis
  • Anti-angiogenic therapy
  • Glycolysis
  • LKB1-AMPK pathway

ASJC Scopus subject areas

  • Biochemistry

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