The effects of captopril treatment (50 mg once daily or BID) on plasma lipoproteins and glucose and insulin responses to oral glucose loading were assessed in 15 patients with mild hypertension. No changes in lipid or lipoprotein levels were observed after eight and 16 weeks of captopril treatment. At the end of the study, postload glucose levels were significantly lower at 60, 90, and 180 minutes. The area under the curve was also significantly smaller. The early insulin response to oral stimulus was higher (P <0.05 at 60 minutes) on captopril treatment, whereas the late insulin response and the area under the curve were unchanged. The results are consistent with a captopril-induced enhancement of insulin-mediated glucose disposal. Antihypertensive treatment with captopril appears to exert no effects or even favorable effects on some of the metabolic derangements often associated with essential hypertension and therefore to produce an improvement of the whole cardiovascular risk profile in hypertensive patients.
|Number of pages||7|
|Journal||Current Therapeutic Research|
|Publication status||Published - 1991|
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