Metabolic effects of the combination of captopril and hydrochlorothiazide in hypertensive subjects

G. Perani, A. Martignoni, C. Muggia, T. Ferrari, P. Simonich, R. Pompei, E. Marchesi, G. Finardi

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Abstract

The medium-term (16 weeks) effects of the combination of captopril and hydrochlorothiazide (HCTZ) on some metabolic indexes, particularly on plasma lipoproteins, were evaluated in 20 mild to moderate hypertensive outpatients. After a 4-week wash-out period, the subjects were given one tablet of a new commercially availabe fixed combination once/daily (i.e., captopril 50 mg + HCTZ 25 mg). The dose could be titrated to a maximum of one tablet twice daily according to individual blood pressure responses. Both systolic and diastolic blood pressure significantly decreased at week 4 and showed a further decrease thereafter, the rate of responders (diastolic blood pressure at or below 90 mm Hg at the end of the study) was very high (90%). The only metabolic change was a small though significant increase in HDL cholesterol (P3 subfraction. The atherogenic fractions, namely total cholesterol, LDL cholesterol, and apoprotein B, showed no significant changes. Plams triglycerides underwent a transient increase at week 8 (P

Original languageEnglish
Pages (from-to)1031-1035
Number of pages5
JournalJournal of Clinical Pharmacology
Volume30
Issue number11
Publication statusPublished - 1990

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ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Perani, G., Martignoni, A., Muggia, C., Ferrari, T., Simonich, P., Pompei, R., Marchesi, E., & Finardi, G. (1990). Metabolic effects of the combination of captopril and hydrochlorothiazide in hypertensive subjects. Journal of Clinical Pharmacology, 30(11), 1031-1035.