Metabolic, electrolytes disorders and tromboembolic risk in malignant glioma patients.

A. Silvani, P. Gaviani, E. Lamperti, A. Botturi, D. Ferrari, G. Simonetti, L. Fariselli, A. Salmaggi

Research output: Contribution to journalArticle

Abstract

In malignant gliomas, the management of symptoms and minimization of side effects assume major importance. Corticosteroids provide transient relief from neurological symptoms. However, treatment with steroids is also commonly associated with considerable side-effects including: hyperglycemia, osteoporosis, myopathy, lymphopenia and others. Sometimes, antiepileptic drugs may contribute to clinical decline of neuro-oncological patients in stable disease not only by neuropsychological impairment but also by metabolic interations. Several studies have demonstrated a high frequency of hyponatremia among patients treated with carbamazepine and particularly with oxacarbamazepine. Venous thromboembolism is a common complication in patients with cancer and it is particularly high in malignant gliomas, occurring in approximately 20-30% of such patients. Prophylactic treatment in patients with glioblastoma is a key topic. The role of prophylaxis has not yet been established with certainty. Overall the data show a clear reduction of venous thromboembolic events in patients treated with intermittent pneumatic compression (IPC). The addition of enoxaparin dose of 6.000 UI, starting in the perioperative period, induces an increase of major bleeding events. In the absence of availability of IPC, the use of enoxaparin 4.000 UI in addition to graduated compression stockings, reduces thromboembolic events without major bleeding events.

Original languageEnglish
JournalNeurological Sciences
Volume32 Suppl 2
Publication statusPublished - Nov 2011

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Glioma
Electrolytes
Enoxaparin
Compression Stockings
Hemorrhage
Lymphopenia
Perioperative Period
Hyponatremia
Venous Thromboembolism
Carbamazepine
Muscular Diseases
Glioblastoma
Hyperglycemia
Anticonvulsants
Osteoporosis
Adrenal Cortex Hormones
Steroids
Therapeutics
Neoplasms

ASJC Scopus subject areas

  • Medicine(all)

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Metabolic, electrolytes disorders and tromboembolic risk in malignant glioma patients. / Silvani, A.; Gaviani, P.; Lamperti, E.; Botturi, A.; Ferrari, D.; Simonetti, G.; Fariselli, L.; Salmaggi, A.

In: Neurological Sciences, Vol. 32 Suppl 2, 11.2011.

Research output: Contribution to journalArticle

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AU - Simonetti, G.

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