Metabolic Evolution of Brain Metastasis After Stereotactic Radiosurgery: Mismatch Between F-DOPA and FDG PET

Francesco Cicone; Luciano Carideo; Veronica Villani; Claudia Scaringi; Alessandro Bozzao; Francesco Scopinaro; Giuseppe Minniti

doi:10.1097/RLU.0000000000003070

Metabolic Evolution of Brain Metastasis After Stereotactic Radiosurgery: Mismatch Between F-DOPA and FDG PET

Francesco Cicone, Luciano Carideo, Veronica Villani, Claudia Scaringi, Alessandro Bozzao, Francesco Scopinaro, Giuseppe Minniti

Istituto Regina Elena

Research output: Contribution to journal › Article › peer-review

Abstract

The differentiation between radiation-induced changes and tumor recurrence is a major pitfall of magnetic resonance imaging, which can be overcome by the use of PET. Although amino-acid PET tracers showed several advantages over F-fluorodeoxyglucose in neurooncology, studies comparing these 2 types of radiopharmaceuticals in previously irradiated brain metastases are lacking. Here, we demonstrated a mismatch between 3,4-dihydroxy-6-[F]-fluoro-L-phenylalanine (F-DOPA) and FDG in the first report of a previously irradiated brain metastasis undergoing a longitudinal evaluation by sequential double tracer PET imaging.

Original language	English
Pages (from-to)	557-558
Number of pages	2
Journal	Clinical Nuclear Medicine
Volume	45
Issue number	7
DOIs	https://doi.org/10.1097/RLU.0000000000003070
Publication status	Published - Jul 2020

Keywords

Brain Neoplasms/diagnostic imaging
Diagnosis, Differential
Dihydroxyphenylalanine/analogs & derivatives
Female
Fluorodeoxyglucose F18
Humans
Magnetic Resonance Imaging
Male
Neoplasms, Radiation-Induced/diagnostic imaging
Positron-Emission Tomography
Radiosurgery/adverse effects

Access to Document

10.1097/RLU.0000000000003070

Fingerprint Dive into the research topics of 'Metabolic Evolution of Brain Metastasis After Stereotactic Radiosurgery: Mismatch Between F-DOPA and FDG PET'. Together they form a unique fingerprint.

Cite this

Metabolic Evolution of Brain Metastasis After Stereotactic Radiosurgery : Mismatch Between F-DOPA and FDG PET. / Cicone, Francesco; Carideo, Luciano; Villani, Veronica; Scaringi, Claudia; Bozzao, Alessandro; Scopinaro, Francesco; Minniti, Giuseppe.

In: Clinical Nuclear Medicine, Vol. 45, No. 7, 07.2020, p. 557-558.

Research output: Contribution to journal › Article › peer-review

@article{da39b8d3110947be9edd8c487d226014,

title = "Metabolic Evolution of Brain Metastasis After Stereotactic Radiosurgery: Mismatch Between F-DOPA and FDG PET",

abstract = "The differentiation between radiation-induced changes and tumor recurrence is a major pitfall of magnetic resonance imaging, which can be overcome by the use of PET. Although amino-acid PET tracers showed several advantages over F-fluorodeoxyglucose in neurooncology, studies comparing these 2 types of radiopharmaceuticals in previously irradiated brain metastases are lacking. Here, we demonstrated a mismatch between 3,4-dihydroxy-6-[F]-fluoro-L-phenylalanine (F-DOPA) and FDG in the first report of a previously irradiated brain metastasis undergoing a longitudinal evaluation by sequential double tracer PET imaging.",

keywords = "Brain Neoplasms/diagnostic imaging, Diagnosis, Differential, Dihydroxyphenylalanine/analogs & derivatives, Female, Fluorodeoxyglucose F18, Humans, Magnetic Resonance Imaging, Male, Neoplasms, Radiation-Induced/diagnostic imaging, Positron-Emission Tomography, Radiosurgery/adverse effects",

author = "Francesco Cicone and Luciano Carideo and Veronica Villani and Claudia Scaringi and Alessandro Bozzao and Francesco Scopinaro and Giuseppe Minniti",

year = "2020",

month = jul,

doi = "10.1097/RLU.0000000000003070",

language = "English",

volume = "45",

pages = "557--558",

journal = "Clinical Nuclear Medicine",

issn = "0363-9762",

publisher = "Lippincott Williams and Wilkins",

number = "7",

}

TY - JOUR

T1 - Metabolic Evolution of Brain Metastasis After Stereotactic Radiosurgery

T2 - Mismatch Between F-DOPA and FDG PET

AU - Cicone, Francesco

AU - Carideo, Luciano

AU - Villani, Veronica

AU - Scaringi, Claudia

AU - Bozzao, Alessandro

AU - Scopinaro, Francesco

AU - Minniti, Giuseppe

PY - 2020/7

Y1 - 2020/7

N2 - The differentiation between radiation-induced changes and tumor recurrence is a major pitfall of magnetic resonance imaging, which can be overcome by the use of PET. Although amino-acid PET tracers showed several advantages over F-fluorodeoxyglucose in neurooncology, studies comparing these 2 types of radiopharmaceuticals in previously irradiated brain metastases are lacking. Here, we demonstrated a mismatch between 3,4-dihydroxy-6-[F]-fluoro-L-phenylalanine (F-DOPA) and FDG in the first report of a previously irradiated brain metastasis undergoing a longitudinal evaluation by sequential double tracer PET imaging.

AB - The differentiation between radiation-induced changes and tumor recurrence is a major pitfall of magnetic resonance imaging, which can be overcome by the use of PET. Although amino-acid PET tracers showed several advantages over F-fluorodeoxyglucose in neurooncology, studies comparing these 2 types of radiopharmaceuticals in previously irradiated brain metastases are lacking. Here, we demonstrated a mismatch between 3,4-dihydroxy-6-[F]-fluoro-L-phenylalanine (F-DOPA) and FDG in the first report of a previously irradiated brain metastasis undergoing a longitudinal evaluation by sequential double tracer PET imaging.

KW - Brain Neoplasms/diagnostic imaging

KW - Diagnosis, Differential

KW - Dihydroxyphenylalanine/analogs & derivatives

KW - Female

KW - Fluorodeoxyglucose F18

KW - Humans

KW - Magnetic Resonance Imaging

KW - Male

KW - Neoplasms, Radiation-Induced/diagnostic imaging

KW - Positron-Emission Tomography

KW - Radiosurgery/adverse effects

U2 - 10.1097/RLU.0000000000003070

DO - 10.1097/RLU.0000000000003070

M3 - Article

C2 - 32371619

VL - 45

SP - 557

EP - 558

JO - Clinical Nuclear Medicine

JF - Clinical Nuclear Medicine

SN - 0363-9762

IS - 7

ER -