Metabolic Evolution of Brain Metastasis After Stereotactic Radiosurgery: Mismatch Between F-DOPA and FDG PET

Francesco Cicone, Luciano Carideo, Veronica Villani, Claudia Scaringi, Alessandro Bozzao, Francesco Scopinaro, Giuseppe Minniti

Research output: Contribution to journalArticlepeer-review

Abstract

The differentiation between radiation-induced changes and tumor recurrence is a major pitfall of magnetic resonance imaging, which can be overcome by the use of PET. Although amino-acid PET tracers showed several advantages over F-fluorodeoxyglucose in neurooncology, studies comparing these 2 types of radiopharmaceuticals in previously irradiated brain metastases are lacking. Here, we demonstrated a mismatch between 3,4-dihydroxy-6-[F]-fluoro-L-phenylalanine (F-DOPA) and FDG in the first report of a previously irradiated brain metastasis undergoing a longitudinal evaluation by sequential double tracer PET imaging.

Original languageEnglish
Pages (from-to)557-558
Number of pages2
JournalClinical Nuclear Medicine
Volume45
Issue number7
DOIs
Publication statusPublished - Jul 2020

Keywords

  • Brain Neoplasms/diagnostic imaging
  • Diagnosis, Differential
  • Dihydroxyphenylalanine/analogs & derivatives
  • Female
  • Fluorodeoxyglucose F18
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Neoplasms, Radiation-Induced/diagnostic imaging
  • Positron-Emission Tomography
  • Radiosurgery/adverse effects

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